Serum and colostrum lysozyme activity was determined in primiparous cows employing a lysoplate method described elsewhere. Samples from 336 animals were collected over a 5-year period from a research station. The animals were sired by 20 elite bulls, one of which (1893) is probably heterozygous for a dominant high lysozyme level gene. The resulting two-population split of high and low level offspring from 1893 is also consistent for the present cow material both in serum and colostrum. A highly significant overall correlation (P less than 0.01) between serum and colostrum lysozyme was estimated. Positive correlation was also found within families and this was particularly high for 1893. No association between serum and colostrum lysozyme activity could be detected when high level animals were excluded. This means that the genetic association between lysozyme activity in the two body fluids is solely dependent upon the major gene described. Consequently, selection of bulls for serum lysozyme activity will influence the colostrum or milk lysozyme activity in the cow population, provided that the major gene is present in the population.

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The main objective of the study is to enhance the mevastatin production using Plackett–Burman (PB) and central composite design (CCD) by Aspergillus terreus in submerged fermentation (SmF). Eight nutrients were chosen for a PB design with 12 experimental runs. A maximum mevastatin production of 170.4 mg L−1 was obtained in PB design. Response surface methodology (RSM) is a sequential procedure with an initial objective to lead the experimenter rapidly and efficiently along a path of improvement toward the general vicinity of the optimum. The individual and interactive effects of these variables were studied by conducting the fermentation run at randomly selected and different levels of all five factors. Experiments were conducted to optimize the medium constituents like glycerol, CuCl2·2H2O, FeSO4·7H2O, KH2PO4 and MgSO4·7H2O. At the optimum condition, a maximum mevastatin production of 701 mg L−1 was obtained.

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