Background: Metabolic syndrome (Mets) is a risk factor for cardiovascular, chronic lung, liver and kidney diseases. Hypercalcaemia, hypomagnesaemia and elevated C-reactive protein (CRP) produce various complications such as cardiac arrythmia, renal stones, atherosclerosis, Diabetes Mellitus, Obesity etc. Some researchers suggested that hypercalcaemia, hypomagnesaemia and elevated CRP occur in Metabolic syndrome patients. Objectives: To measure serum calcium, magnesium and CRP levels in Metabolic syndrome patients. Methods: This cross sectional study was conducted from March 2019 to July 2020 in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU), Shahbag, Dhaka. For this study, 30 female metabolic syndrome patients aged 25 to 45 year, from the Outpatient department of Endocrinology of BSMMU were selected. For comparison, 30 age and gender matched apparently healthy female subjects were control. Serum calcium and magnesium were measured by Colorimetric method and serum CRP was measured by Immunoturbidimetric method. Independent sample‘t’ test was performed for serum calcium and Mann-Whitney U test was performed for serum magnesium and CRP. Results: Mean serum calcium (p £0.05 and median value of serum CRP (p £0.01) were significantly higher, median value of serum magnesium was lower (p>0.05) but not significant in Metabolic syndrome patients than that of control. Conclusion: This study may conclude that elevated serum calcium and CRP levels are associated with metabolic syndrome patients. J Bangladesh Soc Physiol. 2022, June; 17(1): 14-20
Background: Metabolic syndrome (MetS) is a cluster of interconnected risk factors that adversely affects all the organs of the body. Oxidative stress resulting from excess tissue iron causing insulin resistance, tissue damage and other complications are observed in MetS. Objectives: To assess iron status by serum iron, ferritin, total iron binding capacity (TIBC) and transferrin saturation (TS) levels in female MetS patients. Method: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from March, 2019 to February, 2020 on total thirty female MetS patients aged 25 to 45 years. Thirty (30) age matched apperantly healthy female subjects were enrolled as control. Serum iron, ferritin levels, TIBC and TS were measured by standard biochemical methods. Data were expressed as mean ± SD. Statistical analysis was done by Independent sample ‘t’ test. Results: In this study, mean serum ferritin was significantly higher (p<0.001) and mean serum TIBC was significantly lower (p<0.05) in patients than that of controls In addition, 43.3% of MetS patients had excess ferritin and 26.67% patients had low TIBC whereas no control subjects had abnormal ferritin or TIBC and the difference between MetS and control was statistically significant. Conclusion: From the results of this study it can be concluded that higher iron status may be associated with metabolic syndrome. J Bngladesh Soc Physiol 2021;16(1): 82-87
Background: Enteric fever affects more than 11 million children and adults globally each year. Typhoid fever is treated with antibiotics. Ideally, treatment should be safe and available for adults and children in shortened courses of 5 days, cause defervescence within 1 week, render blood and stool cultures sterile, and prevent relapse. Objective: To compare the outcome of azithromycin and ciprofloxacin for treatment of uncomplicated typhoid fever. Method: This comparative intervention was done at tertiary hospital where one hundred patients ranging in age from 5 to 25 years were enrolled in the study and randomly assigned to one of the two treatment groups. Group A constituted of 50 patients receiving azithromycin and group B constituted of the other 50 patients receiving ciprofloxacin. All patients underwent blood cultures or stool cultures from which S. typhi or S. paratyphi was isolated, and these subjects comprised the basis for analysis. Results: During the study, majority of the patients belonged to 5-15 years age group. 50% cases lived in semi pucca buildings followed by 70% drank supply water without boiling and 80% cases were accustomed to homemade food and outside food. Moreover, significance association was noticed in food habit and water source of the patients. In group A, 50 cases showed positivity in salmonella typhi and their mean duration of hospital stay was 10 days. Similarly, in group B, 50 cases showed positivity in salmonella typhi and mean duration of hospital stay was 9.0 days. In group A, 90% were cured by day 7 plus no relapse cases were found. In group B, 80% were cured by day 7. Mild-to- moderate adverse events, all of which were short-term and self-limited were reported equally in both treatment groups. Conclusion: Our results indicated that azithromycin and ciprofloxacin were similarly effective, both clinically and bacteriologically, against typhoid fever caused by both sensitive organisms and MDR S. typhi.
Background: Metabolic syndrome (MetS) is a complex metabolic disorder and with debilitating effects on many organs including lung function impairment. Hyperhomocysteinaemia is caused by nutritional deficiency of vitamin B12 and folic acid can increase this risk further. Both the metabolic syndrome and hyperhomocysteinaemia adversely affect the lung function. But no study was found in Bangladeshi MetS in this regard. Objective: To assess the relationship of lung function with serum homocysteine, vitamin B12 and folic acid level in metabolic syndrome. Methods: This cross-sectional study was conducted in the department of physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from November, 2019 to April, 2020. A total of 60 female subjects were selected with the age ranging from 25-45 year by purposive sampling. Among them 30 metabolic syndrome patients were included in the study group (group A) and 30 age and sex matched apparently healthy subjects constituted comparison group (group B). Serum homocysteine, vitamin B12, folic acid and other biochemical parameters and the lung function of all subjects were assessed. Data were expressed as mean±SD. Spirometric measures were expressed as percent of predicted value. Statistical analysis was done by Independent sample ‘t’ test and Pearson’s correlation coefficient test. Results: In this study, the mean percentage of predicted value of FVC, FEV1 and, PEFR were significantly lower (p<0.001) in group A than those of group B. The mean serum homocysteine level was higher and vitamin B12 and folic acid level were lower in metabolic syndrome patients compared to comparison group and the difference was statistically significant only for homocysteine (p<0.05). In addition, the FVC and FEV1 were significantly negatively correlated (p<0.05) with serum homocysteine and FVC was significantly positively correlated (p<0.05) with serum folic acid level in group A. Conclusion: The present study reveals that impairment of lung function is related to higher level of homocysteine and lower level of folic acid in metabolic syndrome. Bangladesh Med Res Counc Bull 2021; 47(2): 175-180
Several vaccines have been approved against COVID-19 infectious disease and are being given to pop-ulations in different regions of the world. But, the number of people getting vaccines are quite less than the targeted population for whom the vaccines are being kept for immunization purpose. Therefore, the study aimed to investigate the attitude and perceived risk towards COVID-19 vaccination decision in Bangladesh. An exploratory population-based survey was conducted among 186 general individuals chosen purposively from the metropolitan area of Dhaka. The survey was conducted using a structured and self-administered questionnaire. Multiple linear regression technique was performed to determine the variables predicting immunization decision. The findings reflect a significant positive attitude along with insignificant risk-taking behaviour towards COVID-19 immunization decision among the general population in Bangladesh.
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