The authors wish to acknowledge the contribution of: Lijuan Fan for technical assistance, Dmitry Rumyancev for 26 artwork design, and Jianjiang Hao for MS analysis.
Abstract
41The underlying molecular mechanisms that placental growth factor (PlGF) mediates the early complications at non-42 proliferative diabetic retinopathy (DR) remain largely elusive. The objective of this study is to characterize 43 expression profile due to PlGF ablation in the retina of diabetic mice. The quantitative label-free proteomics was 44 carried out on retinal tissues collected from mouse strains (Akita; PlGF -/and Akita.PlGF -/-). We have identified 45 3176 total proteins, and 107 were significantly different between the experimental groups, followed by gene 46 ontology, functional pathways, and protein-protein network interaction analysis. Gnb1, Gnb2, Gnb4, Gnai2, Gnao1, 53 Total words: 175 54 55 56 57 58
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