The aim of this research was to determine the embryotoxic and teratogenic effects and lethal dose (LD50) of maropitant in ovo, using fertile chicken eggs. The study was designed in two stages, CHEST-I and CHEST-II. For CHEST-I, 210 fertile eggs were divided into seven equal groups; control, saline solution and 5 different doses of maropitant (10, 5, 2.5, 1.25, 0.625 mg/kg) injected groups. For CHEST-II, 150 fertile eggs were divided into five equal groups; control, saline solution and 3 different doses of maropitant (8, 6, 4 mg/kg)-injected groups. Eggs were opened on day 21 of incubation. Maropitant did not cause teratogenicity at any dose, while higher embryonic death rates were observed at doses above 4 mg/kg. The LD 50 dose of maropitant was determined as 7.24 mg/kg. In conclusion, maropitant should only be used after full consideration of risks and benefits in pregnancy.
Imidocarb dipropionate is a carbanilide derivative antiprotozoan drug. The drug is approved for use in animals for the treatment of tick-borne transmitted babesiosis (piroplasmosis) and anaplasmosis. However, its effectiveness against some other microorganisms transmitted by ticks has also been investigated. Although cattle, horses, donkeys, mules, dogs and sheep are defined as target species, they can also be used in other domestic and wild animals. Although it is recommended to use the drug as a single dose, it can be applied 2-3 days later if necessary. The therapeutic index of the drug is narrow, and attention should be paid to the dosage regimen. In this review, it could be tried to give information about the use of imidocarb in animal species, its success in treatment and its side effects.
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