Background: The use of herbal medicines (medicinal plants or phytotherapy) has recently gained popularity in Europe and the United States. Nevertheless the exact mechanism of the preventive effects of these products is still far to be clearly established, being its knowledge necessary to successfully apply these therapies to avoid stone formation.
Despite considerable progress in medical therapy, there is no satisfactory drug to treat kidney stones. Therefore, the current study aimed to look for an alternative by using Trigonella foenum graecum (Tfg) on nephrolithiasic rats as a preventive agent against the development of kidney stones, which is commonly used in Morocco as a phytotherapeutic agent. The inhibitory effect of the aqueous extract of Tfg seeds was examined on the formation of calcium oxalate renal stones induced by ethylene glycol (EG) with ammonium chloride. At the end of the experiment all kidneys were removed and examined microscopically for possible crystal/stone locations and the total calcium amount in the renal tissue was evaluated. The blood was recovered to determine the levels of calcium, phosphorus, creatinine and urea. The results showed that the amount of calcification in the kidneys and the total calcium amount of the renal tissue in rats treated with Tfg were significantly reduced compared with the untreated group. Consequently, Tfg may be a useful agent in the treatment of patients with calcic urolithiasis.
The increasing use of geopolymer materials in the construction and civil engineering sectors generates a large amount of non-biodegradable waste that will end up in landfills. It is therefore necessary to anticipate solutions for the proper management of this waste. In this work, new geopolymer materials were fabricated by partially replacing the reactive raw minerals (fly ash, FA, or metakaolin, MK) with used geopolymers (fully fly ash-based, FAref, or metakaolin-based, MKref), in order to develop a strategy to reuse geopolymer waste. Their workability and setting behavior were studied in the fresh state, and the geopolymerization process was investigated by calorimetry and by electrochemistry. Mechanical properties and the ability for coating mineral aggregates were assessed, and the resulting adhesion properties were analyzed using matrix/sand mortars. It appears that the new geopolymer materials as well as the mortars are endowed with good performances. The compressive strengths are above 50 MPa and therefore meet the requirements of different construction materials. This demonstrates the recyclability of geopolymer materials. Moreover, an analysis of the influence of the substitution of recycled geopolymers on the setting and on the mechanical performances of mortars makes it possible to propose a binder-recycled geopolymer interaction model for the formation of new binding matrices.
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