The overall architecture of the gene cluster responsible for epothilone biosynthesis has been determined. The availability of the cluster should facilitate the generation of designer epothilones by combinatorial biosynthesis approaches, and the heterologous expression of epothilones in surrogate microbial hosts.
It is well known that vitamin B6 has significant action on the CNS, and that it is of importance in the metabolism of brain cells. A number of studies on the pharmacological action of vitamin B6 and its derivatives have been reported.2 ,3We had found a method of synthesizing the various 1,2,3, 4tetrahydroisoquinoline derivatives by cyclization of the corresponding carbonyl compounds with 3-hydroxyphenethylamine derivatives 111-VI without acid4-' as a catalyst. We wish to report the synthesis of 1,2,3,4-tetrahydro-l-pyridoxylisoquinoline derivatives (VIII-XI), 4-pyridoxyl-4,5,-6,7-tetrahydro-3H-imidazo[4,5-c]pyridine (VII), and their Ac derivatives, by the applkation of this method using pyridoxal with several 3-hydroxyphenethylamines and hista-CHO
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