Atopic dermatitis is a common chronic dermatosis characterized by a wide variability of endotypes and phenotypes.
Approaches to the treatment of atopic dermatitis are currently undergoing significant changes, especially in patients with moderate and severe forms of atopic dermatitis. JAK inhibitors according to the results of numerous studies have shown their efficacy in the treatment of various immune-mediated dermatological diseases such as atopic dermatitis, vitiligo, focal alopecia and psoriasis, etc.
The article presents the experience of treating adult patients suffering from a severe form of atopic dermatitis with the selective JAK-1 inhibitor upadacitinib. The observations presented are of particular interest due to the fact that the patients were treated with upadacitinib monotherapy. It should be noted that the drug is highly effective against itching. No adverse events (including the development of infectious diseases, hematological disorders) were registered during dynamic observation (according to the results of laboratory studies).
THE AIM: To study the state of the proand antioxidant system at the systemic and local level in acute serous and purulent pyelonephritis (ASP, APP). PATIENTS AND METHODS. Oxidative status was studied in 62 patients with ASP and APP, randomized by age, sex, the minimum number of co-morbidities in remission. RESULTS. It was found that the ASP, to a greater extent with the APP on the system (blood plasma, red blood cells) and local level (urine) increases the concentration of stable metabolites of nitric oxide, increases the content of lipid peroxidation products (alkyl hydroperoxides, malonic dialdehyde) and decreases the activity of the antioxidant system (superoxide dismutase levels, catalase, in plasma, urine and erythrocytes). After the comprehensive treatment of the studied indices at ASP are corrected or normalized, and at APP are subject to a minimum correction. CONCLUSION. The results reveal changes of oxidative status occurring in acute serous and purulent pyelonephritis, and also confirm the need for the comprehensive treatment of this disease using drugs with antioxidant and cytoprotective effects.
Федеральное государственное бюджетное учреждение «Медицинский научно-образовательный центр Московского государственного университета имени М.В . Ломоносова», 119192, г. Москва, Российская Федерация 2 Федеральное государственное бюджетное учреждение дополнительного профессионального образования «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации, 121359, г. Москва, Российская Федерация 3 Федеральное государственное бюджетное учреждение дополни тельного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации, 125993, г. Москва, Ро ссийская Федерация
РезюмеРассмотрены основные виды дерматологических иммуноопосредованных нежелательных явлений, возникающих на фоне проведения современной иммунотерапии злокачественных новообразований ингибиторами контрольных точек PD-1/PD-L1. Представлены клинические случаи, изложены подходы к наружной и системной терапии больных с данным типом иммуноопосредованных побочных эффектов. Представлен алгоритм ведения пациентов с дерматологическими нежелательными явлениями иммунотерапии с учетом клинической картины и степени тяжести.
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