BACKGROUND The size of platelets in circulation is indicated by Mean Platelet Volume (MPV). It is automatically measured while doing complete blood count in auto analyser. Newborn babies of mothers having risk factors for sepsis are screened for early detection of sepsis. Early signs and symptoms of septicaemia are nonspecific. Hence MPV as an additional parameter of neonatal sepsis will be very much valuable. This study aims to determine the role of Mean Platelet Volume as an additional marker in the diagnosis of neonatal sepsis (NS). METHODS This case-control study was conducted over a period of two years at Neonatal Intensive care Unit (NICU), Institute of Maternal and Child Health, Government Medical College, Calicut, Kerala. A total of 445 newborns were divided into 3 groups: Group A-Culture proven NS (n = 39), Group B-Clinical NS (n =183), and Group C-Apparently healthy control (n = 223). All patients in Group A & B were subjected to adequate assessment of history, full clinical examination, complete blood count including MPV, C-reactive protein (CRP) and blood culture. In group C, complete blood count including MPV was done and other investigations relevant to the case. RESULTS Septic neonates showed statistically higher values of MPV than control group. The diagnostic cutoff values of MPV for neonatal sepsis was taken as 10 fL. The mean MPV in culture proven NS (group A) was 10.9467. In clinical NS (group B) it was 10.4021 and in control (group C) it was 9.3509. CONCLUSIONS This study shows that MPV has a role as an additional marker in the diagnosis of neonatal sepsis.
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