Purpose: Red wine may benefit health due to the presence of polyphenolic compounds. This research investigated effects of wine (W) versus grape juice (J) on body composition, blood lipids (cholesterol, HDL, LDL, and triglycerides [TG]), vascular responses (augmentation index [AIx] and central pulse wave velocity [cPWV]), inflammation (C-reactive protein [CRP]), and plasma antioxidant capacity (ferric-reducing ability of plasma [FRAP]) in sedentary individuals. Methods: In a randomized crossover design, 19 participants consumed 300 mL of W or J for two weeks and then acutely in the lab. Blood was drawn at baseline, post two weeks, and within 1 hr after consuming treatment. Repeated measures ANOVA with 2 (treatment) × 3 (time) was used for FRAP, AIx, and cPWV and 2 (treatment) × 2 (time) for blood lipids and CRP. A paired t-test was used to compare differences in diet and weight change. Results: Acute, but not chronic, consumption of wine significantly increased FRAP (treatment P = 0.028) and significantly decreased AIx (treatment P = 0.038) while juice exhibited no effects. An overall treatment effect existed for TG (P = 0.028) in wine only. Cholesterol, LDL, HDL, and CRP were not affected in either group. Conclusion: Acute, but not chronic, consumption of wine significantly increased antioxidant capacity and resulted in beneficial changes to the vasculature as determined by AIx.
Antioxidant supplementation has been shown to reduce blood pressure. Moderate intensity aerobic exercise also elicits a reduction in blood pressure immediately following exercise, termed post exercise hypotension (PEH). The purpose of this study was to test the effects of a multi‐flavonoid supplement plus exercise on PEH following a 2‐week dosing period.Methods12 normotensive subjects between the ages of 18–24 were randomized into either a placebo or a multiflavonoid supplement. Each subject was studied pre, immediately before and after exercise and at 30 minutes post‐exercise both prior to and following 2 weeks supplementation. Blood was taken both pre and immediately following the exercise sessions and was assayed for ferric reducing antioxidant power (FRAP) and the oxygen radical absorbance capacity (ORAC).ResultsSignificant decreases in systolic blood pressure in the treatment vs. placebo group (−3 ± 0.44 mmHg vs. −0.3 ± 0.56 mmHg, respectively, interaction p = 0.05,) and significant increases in FRAP (742 ± 41 to 956 ± 46 μmol/L vs. 658 ± 41 to 670 ± 46 μmol/L, interaction p=0.024) were found following supplementation and no differences in the control group. ORAC produced no significant differences with supplementation.ConclusionsThese data suggest that Q‐EGCG supplementation increases FRAP in young normotensives which may be a mechanism for the resting blood pressure reduction.
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