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Suggestions about determining the concentration of 10B in blood via the thermal neutron flux depression measurement (NFDM) are made. The use of a measuring set-up consisting of a 252Cf neutron source, polyethylene moderator and a slim BF3 counter surrounded by an annular sample is examined. It is shown experimentally that using 6 ml samples and the source emitting 1.4 x 10(7) neutrons s(-1), one can determine the concentration of 10B in water at the level of 10 ppm with a statistical precision of 10% in about 20 min. Monte Carlo simulations performed with the use of MCNP-4C code revealed a potential for further improvements of the NFDM technique both in respect of the sample volume and counting period.

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