Objetivo: Revisar os principais imunobiológicos utilizados para o tratamento da asma grave na população pediátrica. Revisão bibliográfica: A asma grave ainda prevalece como grande causa de morbidade na infância. A utilização de imunomoduladores tem obtido grandes resultados positivos, especialmente o Omalizumabe, medicamento que possui maior número de pesquisas e benefícios comprovados. Desde que o Omalizumabe foi aprovado para o manejo da asma, diferentes terapias biológicas revolucionaram a abordagem terapêutica de doenças alérgicas graves não controladas em crianças. Fármacos como Mepolizumabe, Reslizumabe, Benralizumabe e Dupilumabe ainda estão em contínuos testes clínicos e futuramente podem ser terapêuticos para populações pediátricas específicas e a solucionar as principais incertezas que os imunobiológicos apresentam acrescentados nos protocolos. Considerações finais: Torna-se evidente, portanto, que os imunobiológicos representam uma alternativa promissora para o tratamento da asma severa pois objetivam tratar especificamente as vias inflamatórias da asma. No entanto, estudos comparativos são necessários para ajudar os médicos a escolher a melhor opção.
The strategy described in the present paper offers details about the possibility for Brazil to play a more substantial role in the gene revolution. If successfully applied, the powerful science-based technology currently available in Brazil can contribute to extend the benefits of the gene revolution to the poorest countries, very much like the Green Revolution did in the past, thereby reducing the hunger syndrome which claimed the lives of millions of people in some Asian countries, particularly Pakistan and India, decades ago. In his visit to Brazil in February 2004, Norman Borlaug had the opportunity to witness the success of Brazilian agriculture. At a Conference held at ESALQ -Superior School of Agriculture Luiz de Queiroz in Piracicaba, SP, Brazil, he stated that the 21st century revolution will come from Brazil in the area of agriculture. He also said that reducing hunger is essential for the world to achieve socioeconomic stability. A central question remains unanswered: who will fund this revolution? The FAO 2003 Annual Report listed the barriers preventing the gene revolution from reaching the poorest countries: inadequate regulatory procedures -Intellectual Property Rights and Biosafety, poorly functioning seed delivering systems and weak domestic plant breeding capacity; all are discussed in this paper.
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