RESUMOIntrodução: O mesocarpo de Orbignya phalerata tem sido usado em estudos experimentais procurando verificar sua ação pró-inflamatória. Objetivo: Analisar comparativamente as alterações histológicas proporcionadas pelo extrato aquoso do Babaçu nas feridas cutâneas. Métodos: Sessenta ratos da linhagem Wistar, adultos, machos, foram utilizados. O procedimento experimental constituiu-se em uma incisão circular de 2cm de diâmetro na pele com punch metálico. Após este procedimento comum a todos, os animais foram distribuídos aleatoriamente em dois grupos contendo 30 animais cada. No grupo controle não foi utilizada a substância pesquisada e sim, solução fisiológica (Cloreto de sódio a 0,9%). No grupo experimento utilizou-se solução aquosa de Orbignya phalerata em uso tópico. Os animais foram acompanhados e mortos em sete, 14 e 21 dias. Foi feita análise histológica comparativa entre os grupos. Resultados: Observou-se diferença significativa a favor da cicatrização do grupo experimento em relação ao grupo controle nos 7º e 14º dias, no que diz respeito à reepitelização. Conclusão: O uso tópico do mesocarpo de Orbignya phalerata (Babassu) contribuiu positivamente para a cicatrização das feridas cutâneas em ratos com a dosagem de 25mg/ml. Descritores: Orbignya phalerata. Cicatrização de Feridas. Pele. Ratos. ABSTRACT Introduction:The mesocarp of Babassu (Orbignya phalerata) has been used in experimental studies trying to check its pro-inflammatory effect. Purpose: To analyse comparatively the histological changes made by the water extract of Babassu in skin surgical wounds. Methods: Sixty Wistar adults male rats were used. The experimental procedure was a circle skin incision of 2 cm in diameter made with a metal punch. After this procedure done in all animals, they were randomized in two groups of 30. In the control group, the phytotherapic agent wasn't used but saline solutin. In the experimental group, the water extract of Orbignya phalerata was used in the cut sites. All animals were followed and killed after seven, 14 and 21 days. Comparative histological analysis was made among the groups. Results: In the microscopic view, a significant reepitelization effect on the healing process of the experimental group in relation to the control group in the 7 th and 14 th days, was recognized. Conclusion: The use of the mesocarp of Orbignya phalerata in skin surgical wounds contributed positively in the healing process in rats. Key words: Orbignya phalerata. Wound Healing. Skin. Rats. IntroduçãoA capacidade de reparação tecidual é fenômeno observado nos seres vivos e de grande importância para sua sobrevivência quando ocorrem lesões acidentais ou cirúrgicas.A cicatrização dos tecidos e órgãos constitui-se em um processo biológico complexo essencial para manter a integridade do organismo, mas que ainda não está totalmente esclarecido.Ao longo dos séculos, procurou-se verificar a ação de substâncias químicas e/ou de procedimentos que pudessem agilizar o processo, quer na ferida limpa, quer na contaminada ou infectada 1 . C...
A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra 1 ) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum etiology. Efficacy was assessed on the basis of responses to the 15-item International Index of Erectile Function (IIEF) questionnaire, completed at baseline and after 12 weeks of treatment. At end point, mean scores for all IIEF domains of sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were significantly (P < 0.0001) higher in the sildenafil group (n ¼ 109) than in the placebo group (n ¼ 105). These findings confirm the significant increases in frequency of penetration and frequency of maintained erections reported previously. Sildenafil treatment was well tolerated. The most common adverse events were headache and flushing. In conclusion, sildenafil is a well-tolerated and effective treatment for ED of broad-spectrum etiology in Latin American men.
Introduction This is a phase III, prospective, randomized, double-blind, placebo-controlled clinical trial on lodenafil carbonate (LC), a novel phosphodiesterase 5 inhibitor developed in Brazil. Aim Expanding information on LC efficacy and safety. Main Outcome Measures International Index of Erectile Function (IIEF) erectile domain, positive answers to the sexual encounter profile (SEP)-2 and SEP-3 questions and incidence of adverse events (AEs). Methods A total of 350 men with erectile dysfunction (ED) of all degrees were randomized to placebo, LC 40 mg or LC 80 mg and followed for 4 weeks. They completed the IIEF and answered the SEP questions 2 and 3 after each intercourse without and with the use of LC. Results IIEF Erectile Domain scores without and with the use of medication were the following (mean [M] ± standard deviation [SD]): placebo=13.9 ± 5.2 and 14.8 ± 7.8; LC 40 mg=13.6 ± 5.3 and 18.6 ± 8.0; LC 80 mg=13.4 ± 4.9 and 20.6 ± 7.7 (analysis of variance [anova]P <0.01). Positive answers to SEP-2 without and with the use of medication were the following (M ± SD): placebo=55.3 ± 43.2% and 52.1 ± 41.4%; LC 40 mg=46.4 ± 44.3% and 63.5 ± 42.0%; LC 80 mg=50.2 ± 40.9% and 80.8 ± 32.3% (anovaP <0.01). Positive answers to SEP-3 were the following: placebo=20.2 ± 32.3% and 29.7 ± 38.1%; LC 40 mg=19.6 ± 34.3% and 50.8 ± 44.4%; LC 80 mg=20.8 ± 33.2% and 66.0 ± 39.3% (anovaP <0.01). The patients with at least one AE were placebo=28.7%, LC 40 mg=40.9%, and LC 80 mg=49.5%. AEs whose incidence was significantly higher with LC than with placebo included rhinitis, headache, flushing, visual disorder, and dizziness. Conclusions LC showed a satisfactory efficacy–safety profile for oral therapy of ED.
Efeito do extrato de ABSTRACT Purpose:To evaluate the effects of hydroalcoholic extract of Passiflora edulis leaves in the healing of urinary bladder in rats from histological aspects. Methods: Forty Wistar male rats were submitted to a longitudinal incision of the bladder followed by a stetching in only one level. After this common procedure, animals were divided at random two groups: Passiflora and Control. In the Passiflora group the only dosage used was administered by intraperitonial injection of hydoalcoholic extract of Passiflora edulis leaves while in the Control group distilled water was injected. Each subgroup was then divided in two subgroups according to the death of these animals: Control, three and seven days, Passiflora, three and seven days. After the death of these animals, an inventory of the abdominal cavity was performed and the bladder was removed. A comparative analysis was done between the two groups with microscopic evaluation of the healing. There was less acute inflammation (p=0.008), greater colagenous formation (p=0.001) and greater capillary neo-formation (p=0.000) in the third day Passiflora subgroup when compared to the Control subgroup of the third day. Results: There was less acute inflammation (p=0.001), greater fibroblastic proliferation (p=0.011) and greater colagenous formation (p=0.001) in the Passiflora subgroup of seventh day when compared with the Control seventh day subgroup. Conclusion: The use of Passiflora edulis leaves extract resulted in less acute inflammation, greater fibroblastic proliferation, colagenous formation and capillary neo-formation on rats bladder wound healing. Key words: Passiflora edulis. Wound Healing. Bladder. Rats. IntroduçãoA cicatrização é um processo que visa limitar os danos e restabelecer a integridade e a função dos tecidos afetados 1 .Os avanços da biologia celular e molecular têm permitido o estudo e ampliado o conhecimento das etapas da cicatrização. Sabe-se que os tecidos cicatrizam-se de maneira
The time factor of wound healing showed homogeneity between experimental and control groups, however faster in the experimental one. The Orbignya phalerata had a favoring healing effect in the surgical incision on rats bladder.
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