Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1-deficient mice (Ppt1 −/− ) and the development of their seizure phenotype. Surprisingly, cortical atrophy and neuron loss occurred only late in disease progression, but were preceded by localized astrocytosis within individual thalamic nuclei and the progressive loss of thalamic neurons that relay different sensory modalities to the cortex. This thalamic neuron loss occurred first within the visual system and only subsequently in auditory and somatosensory relay nuclei or the inhibitory reticular thalamic nucleus. The loss of granule neurons and GABAergic interneurons followed in each corresponding cortical region, before the onset of seizure activity. These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1 −/− mice, revealing the thalamus as an important early focus of INCL pathogenesis.

Professionals who work in mental health settings are at risk of developing psychological distress themselves. The term “compassion fatigue” has been used to describe the negative effects of working in a psychologically distressing environment on a person’s ability to feel compassion for others. A number of studies have investigated predictors and correlates of compassion fatigue. However, as yet there is no consensus on which psychosocial factors are most commonly related to compassion fatigue. This review examines research on common correlates and predictors of compassion fatigue in mental health professionals. A literature search yielded 32 studies describing compassion fatigue in a range of mental health professionals and in relation to a variety of psychosocial factors. Quality of papers was variable. The review highlights several factors that were commonly associated with compassion fatigue (e.g., trauma history of mental health professionals, empathy). Some potential protective factors were also indicated, including certain behavioral and cognitive coping styles and mindfulness. Findings and implications are discussed, and directions for future studies are indicated. In particular, we highlight the need for longitudinal studies to investigate compassion fatigue’s development over time and to test models of the etiology of compassion fatigue.

Police officers who work with victims of rape and sexual assault are exposed to severely traumatic material. This study aimed to investigate whether these specialist officers had developed compassion fatigue, secondary traumatic stress and burnout, and whether these variables were associated with trait and situational empathy, an important factor in retaining victim involvement within the prosecution process. The study also piloted a brief training intervention aimed at educating officers about compassion fatigue and ways of reducing and preventing it. A convenience sample of specialist police officers (N = 142) who work with victims of sexual assault completed measures of compassion fatigue, secondary traumatic stress and burnout, as well as two empathy measures, rating trait empathy and 'in vivo' empathy in response to a video vignette. Cross-sectional analysis showed that longer-serving specialist officers had greater compassion fatigue, secondary traumatic stress and burnout, but that neither measure of empathy was related to compassion fatigue or secondary traumatic stress, although high burnout was related to low trait empathy. The training was well received, and pre and post-test measures showed that officers' knowledge of the constructs increased. Given the potential risks to their well-being and work performance, officers would benefit from further support to cope with and prevent emotional distress. Higher empathy might protect against burnout. Longitudinal research is needed to better understand the relationships between empathy, compassion fatigue, secondary traumatic stress and burnout.

This exploratory study investigated whether rape victims' subjective perceptions of whether to proceed with legal action were associated with their experience of disclosing to the police during their initial interview. Specifically, the study investigated associations between symptoms of PTSD, shame and self-blame post-rape, subjective perceptions of police empathy and subjective perception of victims' intentions to take the case to court. Participants (N=22) were found to have elevated levels of PTSD severity, shame and self-blame. Police empathy was positively correlated with victims' ratings of likelihood of taking the case to court, and negatively correlated with PTSD severity and shame. These preliminary findings suggest that training police officers how to respond more empathically to psychologically distressed rape victims may potentially help reduce victim attrition rates.