No abstract

The aim of the present study was to examine how the home environment, including socioeconomic status (SES), affects motor development in school-age children. Seven hundred seven children (332 boys and 375 girls) aged between 6 and 10 years participated in the study. Motor Development was determined using the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition. Parents answered the Middle Childhood Home Observation Measurement of the Environment (HOME) Inventory, and Brazilian Association of Market Research Institutes Questionnaire (for SES). Children from "Adequate" homes (HOME score), compared with "Less Adequate," displayed better motor behavior. Mediation and moderation analysis revealed that motor development increased as SES increased. The proportion of variance in motor development explained by SES increased from 9% to 13% when the home was added as a mediation variable. We also found that the effect of SES on motor development was moderated by age. For older children, the effect was lower than for younger children. The best model used SES as the predictor, HOME as the mediator, and AGE as the moderator variable and explained 17% of the variance in motor development. In summary, these findings suggest that, like previous reports with young children, the HOME environment and SES may play an important role in motor development of school-age children. Our findings encourage the assessment of the home and interventions that take into account the home environment to improve motor development in school-age children.

Objective To assess whether eculizumab, a terminal complement inhibitor, improves patient‐ and physician‐reported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis across four domains, representing ocular, bulbar, respiratory, and limb/gross motor muscle groups. Methods Patients with refractory anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis were randomized 1:1 to receive either placebo or eculizumab during the REGAIN study (NCT01997229). Patients who completed REGAIN were eligible to continue into the open‐label extension trial (NCT02301624) for up to 4 years. The four domain scores of each of the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale recorded throughout REGAIN and through 130 weeks of the open‐label extension were analyzed. Results Of the 125 patients who participated in REGAIN, 117 enrolled in the open‐label extension; 61 had received placebo and 56 had received eculizumab during REGAIN. Patients experienced rapid improvements in total scores and all four domain scores of both the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale with eculizumab treatment. These improvements were sustained through 130 weeks of the open‐label extension. Interpretation Eculizumab treatment elicits rapid and sustained improvements in muscle strength across ocular, bulbar, respiratory, and limb/gross motor muscle groups and in associated daily activities in patients with refractory anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis.

The purpose of this study was to investigate the association between Sport Participation (SP) and Motor Competence (MC) in school-age children, and to assess the mediation role of Body Mass Index (BMI) on this association. 707 children (332 boys, 375 girls) aged between 6-to 10 years participated in the study. Motor competence was determined using the Bruininks-Oseretsky Test of Motor Proficiency (BOT-2). Parents were asked about organized SP, categorized as 1) no participation, 2) partial participation and 3) consistent participation, and BMI was calculated based on the child's height and weight. The results indicated significant differences for all MC components and total score for SP categories, all p < .05, with higher results for consistent participation in sports. For BMI, significant differences occurred in all components, with the exception of fine manual control and manual coordination. Our findings showed that SP was associated with MC, and BMI was not an important factor in these relationships. However, a small mediation of BMI was found, but only for obese children. In summary, we conclude that sport participation plays a relevant role in the development of motor competence in school-age children, and that association is, in general, not mediated by weight status. Palavras-chave: Motor competence. Body mass index. Sport participation. School-age children. RESUMO O objetivo deste estudo foi investigar a associação entre Participação Esportiva (PE) e Competência Motora (CM) em crianças em idade escolar e avaliar o papel da mediação do Índice de Massa Corporal (IMC) nesta associação. Foram avaliadas 707 crianças (332 meninos, 375 meninas) com idades entre 6 e 10 anos participaram do estudo. A competência motora foi determinada usando o Teste Bruininks-Oseretsky de Proficiência Motora (BOT-2). Os pais foram questionados sobre a SP organizada, categorizada como 1) sem participação, 2) participação parcial e 3) participação consistente, e o IMC foi calculado com base na altura e no peso da criança. Os resultados indicaram diferenças significativas para todos os componentes do CM e escore total para as categorias de PS, todos p <0,05, com resultados mais altos para a participação consistente nos esportes. Para o IMC, ocorreram diferenças significativas em todos os componentes, com exceção do controle manual e da coordenação manual. Nossos achados mostraram que a SP estava associada à CM, e o IMC não foi um fator importante nessas relações. No entanto, uma pequena mediação do IMC foi encontrada, mas apenas para crianças obesas. Concluímos que a participação esportiva desempenha um papel relevante no desenvolvimento da competência motora em crianças em idade escolar, e essa associação, em geral, não é mediada pelo status de peso. Palavras-chave: Competência motora. Índice de massa corporal. Participação esportiva. Crianças em idade escolar.