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Our objective is to understand the notion of type in programming languages, present a model of typed, polymorphic programming languages that reflects recent research in type theory, and examine the relevance of recent research to the design of practical programming languages.Object-oriented languages provide both a framework and a motivation for exploring the interaction among the concepts of type, data abstraction, and polymorphism, since they extend the notion of type to data abstraction and since type inheritance is an important form of polymorphism. We develop a X-calculus-based model for type systems that allows us to explore these interactions in a simple setting, unencumbered by complexities of production programming languages.The evolution of languages from untyped universes to monomorphic and then polymorphic type systems is reviewed. Mechanisms for polymorphism such as overloading, coercion, subtyping, and parameterization are examined. A unifying framework for polymorphic type systems is developed in terms of the typed A-calculus augmented to include binding of types by quantification as well as binding of values by abstraction.The typed X-calculus is augmented by universal quantification to model generic functions with type parameters, existential quantification and packaging (information hiding) to model abstract data types, and bounded quantification to model subtypes and type inheritance. In this way we obtain a simple and precise characterization of a powerful type system that includes abstract data types, parametric polymorphism, and multiple inheritance in a single consistent framework. The mechanisms for type checking for the augmented X-calculus are discussed.The augmented typed X-calculus is used as a programming language for a variety of illustrative examples. We christen this language Fun because fun instead of X is the functional abstraction keyword and because it is pleasant to deal with.Fun is mathematically simple and can serve as a basis for the design and implementation of real programming languages with type facilities that are more powerful and expressive than those of existing programming languages. In particular, it provides a basis for the design of strongly typed object-oriented languages.

Biological organisms use complex molecular networks to navigate their environment and regulate their internal state. The development of synthetic systems with similar capabilities could lead to applications such as smart therapeutics or fabrication methods based on self-organization. To achieve this, molecular control circuits need to be engineered to perform integrated sensing, computation and actuation. Here we report a DNA-based technology for implementing the computational core of such controllers. We use the formalism of chemical reaction networks as a 'programming language', and our DNA architecture can, in principle, implement any behaviour that can be mathematically expressed as such. Unlike logic circuits, our formulation naturally allows complex signal processing of intrinsically analogue biological and chemical inputs. Controller components can be derived from biologically synthesized (plasmid) DNA, which reduces errors associated with chemically synthesized DNA. We implement several building-block reaction types and then combine them into a network that realizes, at the molecular level, an algorithm used in distributed control systems for achieving consensus between multiple agents.

We introduce a calculus describing the movement of processes and devices, including movement through administrative domains.

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The λσ-calculus is a refinement of the λ-calculus where substitutions are manipulated explicitly. The λσ-calculus provides a setting for studying the theory of substitutions, with pleasant mathematical properties. It is also a useful bridge between the classical λ-calculus and concrete implementations.

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