Objetivo: Verificar a relação entre variações do clearance de creatinina (ClCr) e os fatores clínicos de pacientes internados em clínica médica. Material e Método: Estudo longitudinal, do tipo coorte prospectivo, quantitativo, realizado em um hospital público do Distrito Federal. 85 pacientes evoluíram com Lesão Renal Aguda (LRA), de acordo com a classificação Kidney Disease: Improving Glogal Guidelines (KDIGO). O acompanhamento foi até 1 mês pós-alta hospitalar. A gravidade dos pacientes foi medida através do Índice de Comorbidade de Charlson. Considerou-se significativo resultados com p ≤ 0,05. Resultados: 51,8% dos pacientes eram do sexo masculino. Entre as comorbidades se destacaram hipertensão arterial (70,6%), diabetes mellitus (57,6%) e as cardiopatias (52,9%). O tempo de permanência hospitalar (p= 0,001) e a idade (p= 0,05) estiveram associadas a pior função renal. Pacientes com ClCr≤ 30 ml/min estiveram associados a uma maior taxa de mortalidade (p= 0,007). Conclusão: Idade avançada e maior tempo de internação hospitalar se associaram a piora da função renal (ClCr < 60 ml/min). Àqueles com severa piora da função renal (ClCr < 30 ml/min) apresentaram maior taxa mortalidade.
Creatinine is produced by muscle metabolism as a creatine product, being totally excreted by renal route and widely used as an indicator of renal function in mammals. The aim of this study was to evaluate the effect of body condition indicators on the serum creatinine concentration. We evaluated 27 animals, 9 males and 18 females, aged 1 to 12 years, without clinical complaint. Data on weight, body condition score (BCS),canine body mass index (CBMI) and serum urea and creatinine concentrations were analysed. The mean creatinine concentration was 0,97 ± 0,26 mg / dL and urea 41,6 ± 16,5 mg / dL. The majority of the animals had BCS classified as ideal, with a mean of 5,3 ± 1,4 (range of 1 to 9) and mean CBMI of 14,5 ± 3,5. Subsequently the results were grouped into four categories according to weight, P1 (0 to 10 kg), P2 (11 to 20 kg), P3 (21 to 30 kg) and P4 (above 30 kg). There was a significant effect (p <0,05) of the weight class on the creatinine concentration, with lower values in P1 and a strong positive correlation of creatinine with the IMCC (r = 0,66, p <0,001), weight (r = 0,71, p <0,001) and height (r = 0,73, p <0,001). Therefore, in animals with an ideal body score, weight can be used as a criterion for classification of animals for the interpretation of the effect of body mass on the creatinine concentration and it is suggested the possibility of using reference values appropriate to the weight of the animals.
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