Digoxin did not reduce overall mortality, but it reduced the rate of hospitalization both overall and for worsening heart failure. These findings define more precisely the role of digoxin in the management of chronic heart failure.

In this series of patients with tricuspid aortic valve and similar AS severity, women have less valvular calcification but more fibrosis compared with men. These findings suggest that the pathophysiology of AS and thus potential targets for drug development may be different according to sex.

Hood soutient que sa grille d'analyse des instruments (The Tools of Government, Londres, Macmillan, 1983) est toujours pertinente. « Ideas can come back into fashion as well as go out. And older forms of analysis can stand the test of time, particularly if they are not specific to any particular technology or ideology of governance » (Ch. Hood, « Intellectual Obsolescence... », art. cité, p. 128).

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