A short form of the Wechsler Adult Intelligence Scale--Revised (WAIS-R) developed by Ward (WAIS-R/7 SF; 1990) was used to generate Verbal, Performance, and Full Scale IQ scores (VIQ, PIQ, and FSIQ, respectively) in 66 individuals diagnosed with multiple sclerosis (MS). Short-form scores were highly correlated with WAIS-R scores. However, the short-form VIQ and PIQ, but not FSIQ, scores differed significantly from corresponding WAIS-R scores. WAIS-R/7 SF VIQ, PIQ, and FSIQ scores fell within 5, 9, and 6 absolute error points, respectively, of corresponding WAIS-R IQ scores in 95% of cases. Classification of IQ scores into ranges (e.g., average, high average, etc.) based on the scheme outlined by Wechsler (1981) was consistent between WAIS-R/7 SF and WAIS-R scores in 81.8% (for VIQ), 74.8% (for PIQ), and 89.4% (for FSIQ) of cases. These findings are discussed within the context of using the WAIS-R/7 SF in the assessment of MS patients.
Genetic effects of 5-thio-D-glucose (5-thio) were tested in male mice by the dominant lethal gene test. Males were treated with phosphate buffered saline (PBS) or 5-thio dissolved in PBS by oral intubation daily at 40 or 60 mg/kg for 7 or 35 successive days. Average implantations per pregnant female and the intrauterine postimplantation losses in females mated with 5-thio trated males did not show any significant differences when compared statistically with parallel controls. Furthermore, the compound had no effect on the appearance and mating behavior of the male mice. This is the first report on the genetic effects of 5-thio to show that the compound in the treatment regimens studied were not mutagenic in terms of the induction of dominant lethal mutation in male mice.
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