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The bacterial pathogen Legionella pneumophila creates an intracellular niche permissive for its replication by extensively modulating host cell functions using hundreds of effector proteins delivered via its Dot/Icm secretion system 1 . Among these, members of the SidE Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

Highlights d Two cryo-EM structures of CRF1R and CRF2R bound to UCN1 and Gs heterotrimer d Mechanisms of the N-terminal residues of UCN1 in receptor binding and activation d Comparison with the inactive structure reveals conformational changes upon activation d The important role of cholesterols in GPCR signaling is further established

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