The influence of geldanamycin (GA), a specific inhibitor of heat shock protein Hsp90, on the synthesis of Hsp70 and Hsp90 and thermotolerance of Arabidopsis thaliana seedlings has been studied. Incu bation of seedlings with GA under normal conditions induced synthesis of these stress proteins. Treatment of seeds with the Hsp90 inhibitor resulted in elevated constitutive levels of Hsp70 and Hsp90 in seedlings, as well as increased induction of their synthesis under heat shock. The GA effect increased with its concentration. Hsp up regulation promoted thermotolerance of seedlings. The findings suggest autoregulation of heat shock protein synthesis and regulation of plant tolerance by Hsp90.
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