Cholesterol was usually used to stabilize liposome, although there have been controversies on the relationship between dietary cholesterol and health. The present study aimed to prepare a novel multifunctional nanoliposomes stabilized by sea cucumber-derived saponins using ultrasound-assisted film dispersion method. A novel uniform liposome with a mass ratio of egg yolk lecithin/sea cucumber saponins at 75:25 was successfully prepared to encapsulate saponin, and the particle size was 164.8 ± 1.70 nm with a PDI value of 0.214 ± 0.022 and zeta potential of −15.97 ± 1.23 mV. The digestion and absorption results in vivo showed that the dietary saponins in liposome form could delay the peak time of saponins and prolong their residence time in the serum. Moreover, saponins were more easily converted into their corresponding metabolites after administration with saponins in the liposome form. The novel liposome as an efficient carrier with multiple functions had great potential in the development of functional food and biomedical applications.

Viral diarrhea is one of the leading causes of morbidity and mortality in children. This study was conducted to disclose the etiological cause and epidemiological features of viral diarrhea among children in China. From 2009 to 2021, active surveillance was performed on pediatric patients with acute diarrhea and tested for five enteric viruses.Positive detection was determined in 65.56% (3325/5072) patients and an age-specific infection pattern was observed. A significantly higher positive rate was observed in 12-23-month-old children for rotavirus (47.46%) and adenovirus (7.06%), while a significantly higher positive rate was observed for norovirus (37.62%) in 6-11-monthold patients, and for astrovirus (11.60%) and sapovirus (10.79%) in 24-47-month-old patients. A higher positive rate of rotavirus in girls and norovirus in boys was observed only among 6-11 months of patients. We also observed more norovirus among patients from rural areas in the 0-5-and 36-47-month groups and more rotavirus among those from rural areas in the 12-23-month group. Diarrhea severity was greater for rotavirus in the 6-23-month group and norovirus in the 6-11-month group. Coinfections were observed in 29.26% (973/3325) of positive patients, and were most frequently observed between rotavirus and others (89.31%). Our findings could help the prediction, prevention, and potential therapeutic approaches to viral diarrhea in children.

The so-called facility location means how to use scientific methods to determine the facility's location, so that the overall business operations and enterprise systems combine to effectively and economically achieve corporate business objectives. This paper introduces the Fuzhou Municipal Bureau of distribution center location tobacco case to be analyzed on the basis of this issue describes the significance of facility location, facility siting factors and principles are analyzed and siting of facilities the methods are summarized proposed general facility siting process steps, facility sitting decisions provide some guidance.

Distribution is an important function of enterprise logistics. Through efficient distribution activities, it can reduce the total cost of logistics enterprises and improve logistics efficiency and service levels. Therefore, the rationality of the logistics and distribution system design will directly affect the survival and development of enterprises. In this dissertation uses a retail business distribution network for the study, to study its distribution optimization models and methods, using a variety of algorithms for analysis, to understand its distribution network efficient mode of operation.

In the context of building an innovative country, innovation and development-oriented enterprise transformation and restructuring of industry information services, creation and innovation for our country to adapt to national construction industry information service system has a theoretical guidance.