Based on Matrix Converter-Permanent Magnet Synchronous Machine (MC-PMSM) speed regulator system simulation platform, this paper investigates the behavior and characteristics of MC-PMSM drive system under the condition of MC switch short-circuit faults. Two isolation strategies by utilizing semiconductors and high speed fuses for MC switch short-circuit faults are. Behavior of MC-PMSM drive system during fuse action time under different operating situations is explored. The feasibility of fault-tolerant operation during fuse action time is studied. Furthermore, the basic selection laws of high speed fuses and requirements of passive components of MC drive systems from the point view of short-circuit faults are also studied in the paper. Simulation results are shown to demonstrate the feasibility of the proposed isolation strategies on the simulation platform of MC-PMSM drive system.