How to cite this article: Bobronnikova L. Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes. Vessel Plus 2017;1:61-7.
Aim:To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate metabolism, insulin resistance parameters and galectin-3 levels were measured. Echocardiography was performed to determine the structural-functional condition of the heart. Estimation of the intima-media complex thickness of the common carotid artery was performed by duplex ultrasound scanning. Results: Hypertrophy of the left ventricular myocardium is most evident in patients with AH and type 2 DM compared with groups 1 and 2, and the control group (P < 0.05). The levels of galectin-3 in the group with concomitant hypertension and type 2 DM were higher than in groups 1 and 2, and the control group (P < 0.05). A positive correlation was revealed between the level of galectin-3, indices of insulin resistance, and structural-functional cardiac and vessel remodeling. Conclusion: Galectin-3 levels in serum are significantly linked with indices of insulin resistance and cardiovascular remodeling.
Key words:Arterial hypertension, type 2 diabetes mellitus, insulin resistance, cardiovascular remodeling, galectin-3
ABSTRACTArticle history:
The aim of the study was to assess the relationship of metabolic parameters and vascular remodeling in patients with comorbidity of essential hypertension (EH), type 2 diabetes and obesity. We were examined 320 patients with EH stage II, grade 2 and type 2 diabetes moderate, subcompensated; 90 patients with EH stage II, grade 2 without type 2 diabetes and 31 healthy individuals. It was found that in comorbidity of EH, type 2 diabetes and obesity lipid and carbohydrate disorders, levels of adipokines and cytokines are linked and are the basis for the progression of the disease and for the beginning of cardiovascular complications, which was confirmed by data of correlation and variance analysis.
Abstract. In the article features of pathogenetic mechanisms of the combined course of arterial hypertension and type 2 diabetes mellitus are considered. This pathology potentiates the development of micro-and macrovascular complications, raises cardiovascular risk. Concomitant abdominal obesity contributes to the imbalance of adipocytokines, and complicates the course of type 2 diabetes. It was established that polymorphism of candidate genes associated with the development and progression of insulin resistance, which is of interest for further study.
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