Headache is a common symptom after cerebral angiography, although it has seldom been studied. We aimed to evaluate the frequency of headache at 24 h and 6 months after angiography and to describe its characteristics. We used a cross-sectional survey of consecutive patients submitted to angiography and determined headache presence and its characterization. Headache occurrence was analyzed against headache history, clinical data, technical and demographical variables. Of 107 procedures studied, 51.3% patients experienced headaches within 24 h. Patients more likely to experience headaches were females or had subarachnoid hemorrhage. Six months post-procedure 48.8% of patients had frequent headaches. These patients had a positive headache history before the procedure, migraine in particular. Half of patients undergoing routine angiography experience benign post-procedure headaches within 24 h (especially women), yet it does not seem to predispose to chronic long-term headaches.

The bullous hemorrhagic dermatosis induced by enoxaparin is a rare adverse reaction, which may be under-reported given its favorable evolution. We report a 71-year-old man who developed hemorrhagic bullae at sites distant from subcutaneous enoxaparin injections. It is important that clinicians be aware of the different adverse reactions of these widely used drugs.

HdEVP is an uncommon brief headache that should be further evaluated in the future. Its pathogenesis is probably related to mechanical vessel distension, which activates the trigeminovascular nociceptive system in susceptible individuals.

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