The primary event following the administration of adrenocorticotropic hormone (ACTH) is the immediate increase in steroid synthesis by the adrenal gland.1 Previous studies by numerous investigators suggested that this action of ACTH was the result of specific activation of enzymes.2' 3 However, studies showing that puromycin or chloramphenicol blocked the stimulation of corticosterone synthesis by ACTH suggested that protein synthesis was involved in this process.4 5 But

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BIOCHEMISTRY: GARREN ET AL. 1121 tions (,10-3 M) of pyruvate will induce prompt and sustained stimulation of sodium transport. Only pyruvate and, to a lesser extent, those substrates known to yield pyruvate during the course of their metabolism, i.e., glucose, lactate, and oxalacetate, have been found to possess this stimulatory effect in the aldosteronetreated bladder. Possibile mechanisms for this effect of pyruvate are considered.

As determined by electron-microscope autoradiography of adrenal glands containing tritiated cholesterol and by modified differential centrifugation techniques, 70 to 80 percent of adrenal cholesterol is contained within lipid droplets of rat adrenal cortical cells.

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