No abstract

A single osteolytic bone tumour with a cellular composition similar to that of the extra-nodal localization of Sinus Histiocytosis with Massive Lymphadenopathy although with greater cellular atypicality is described. This histological similarity suggests the possible occurrence of isolated bone involvement of Rosai-Dorfman disease, with atypical cytology but benign evolution, which has not been reported in the literature.

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We report seven cases of subclinical congenital toxoplasmosis secondary to maternal primary infections. Mothers were infected between two and four weeks prior to delivery. The diagnostic criteria of congenital infections included: IgM antibody (Ab) (1 case); IgM and IgA Ab (1 case); a real IgG seroconversion in the neonatal and postnatal samples (3 cases); persistence of IgG Ab beyond 6 months post-delivery (2 cases). A treatment was initiated, including a combination of pyrimethamine + sulfadiazine (6 cases); trimethoprim + sulfamethoxazole (1 case). This retrospective study suggests that it is important to screen the non-immune pregnant women until delivery. We confirmed the usefulness of a combination of isotypes of antibodies for the accurate assessment of congenital infection. Finally, infected infants have to be treated and monitored clinically and immunologically during the first year of life.