The second-order nonlinear optical responses of a series of recently designed dipolar merocya- nines are investigated using the 2006 Minnesota family of hybrid exchange-correlation functionals (XCFs), as well as the...
The morphology and secondary structure of peptide fibers formed by aggregation of tubulin-associated unit (Tau) fragments (K18), in the presence of the inner cytoplasmic membrane phosphatidylinositol component (PIP 2 )orheparin sodium (HS) as cofactors,a re determined with nanoscale (< 10 nm) spatial resolution. By means of tip-enhanced Raman spectroscopy( TERS), the inclusion of PIP 2 lipids in fibers is determined based on the observation of specific C=Oe ster vibration modes.Moreover,analysis of amide Iand amide III bands suggests that the parallel b-sheet secondary structure content is lower and the random coil content is higher for fibers grown from the PIP 2 cofactor instead of HS.T hese observations highlight the occurrence of some local structural differences between these fibers.T his study constitutes the first nanoscale structural characterization of Tau/phospholipid aggregates,w hich are implicated in deleterious mechanisms on neural membranes in Alzheimersd isease.
Owing to their intense emission, low toxicity and solubility in aqueous medium, fluorescent organic nanoparticles (FONs) have emerged as promising alternatives to inorganic ones for the realization of exogenous probes...
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