BackgroundEffective management of patients with diabetic foot infection is a crucial concern. A delay in prescribing appropriate antimicrobial agent can lead to amputation or life threatening complications. Thus, this electronic nose (e-nose) technique will provide a diagnostic tool that will allow for rapid and accurate identification of a pathogen.ResultsThis study investigates the performance of e-nose technique performing direct measurement of static headspace with algorithm and data interpretations which was validated by Headspace SPME-GC-MS, to determine the causative bacteria responsible for diabetic foot infection. The study was proposed to complement the wound swabbing method for bacterial culture and to serve as a rapid screening tool for bacteria species identification. The investigation focused on both single and poly microbial subjected to different agar media cultures. A multi-class technique was applied including statistical approaches such as Support Vector Machine (SVM), K Nearest Neighbor (KNN), Linear Discriminant Analysis (LDA) as well as neural networks called Probability Neural Network (PNN). Most of classifiers successfully identified poly and single microbial species with up to 90% accuracy.ConclusionsThe results obtained from this study showed that the e-nose was able to identify and differentiate between poly and single microbial species comparable to the conventional clinical technique. It also indicates that even though poly and single bacterial species in different agar solution emit different headspace volatiles, they can still be discriminated and identified using multivariate techniques.
BackgroundVolatile organic compounds (VOCs) emitted from exhaled breath from human bodies have been proven to be a useful source of information for early lung cancer diagnosis. To date, there are still arguable information on the production and origin of significant VOCs of cancer cells. Thus, this study aims to conduct in-vitro experiments involving related cell lines to verify the capability of VOCs in providing information of the cells.MethodThe performances of e-nose technology with different statistical methods to determine the best classifier were conducted and discussed. The gas sensor study has been complemented using solid phase micro-extraction-gas chromatography mass spectrometry. For this purpose, the lung cancer cells (A549 and Calu-3) and control cell lines, breast cancer cell (MCF7) and non-cancerous lung cell (WI38VA13) were cultured in growth medium.ResultsThis study successfully provided a list of possible volatile organic compounds that can be specific biomarkers for lung cancer, even at the 24th hour of cell growth. Also, the Linear Discriminant Analysis-based One versus All-Support Vector Machine classifier, is able to produce high performance in distinguishing lung cancer from breast cancer cells and normal lung cells.ConclusionThe findings in this work conclude that the specific VOC released from the cancer cells can act as the odour signature and potentially to be used as non-invasive screening of lung cancer using gas array sensor devices.
Muscle fatigue is described by the decline in muscle maximum force during contraction. The fatigue occurs in the nervous or muscle fibre cells. The nerves produce a high-frequency signal to gain the maximum contraction, but it cannot sustain the high frequency signal for a long time, and that leads to a decline in muscle force. The surface Electromyography (EMG) is the dominant method to detect muscle fatigue because the EMG signals give more information about the muscle’s activities. This review discussed the EMG signal processing and the methods of detection muscles fatigue with three domains (time domain, frequency domain, and time-frequency domain) based on EMG signals that are collected from the muscles during dynamic and static movements.
Abstract-This paper presents results of a study to characterise wireless point-to-point channel for wireless sensor networks applications in sport hard court arenas, grass fields and on roads. Antenna height and orientation effects on coverage are also studied and results show that for omni-directional patch antenna, node range is reduced by a factor of 2 when the antenna orientation is changed from vertical to horizontal. The maximum range for a wireless node on a hard court sport arena has been determined to be 70 m for 0 dBm transmission but this reduces to 60 m on a road surface and to 50 m on a grass field. For horizontal antenna orientation the range on the road is longer than on the sport court which shows that scattered signal components from the rougher road surface combine to extend the communication range. The channels investigated showed that packet error ratio (PER) is dominated by large-scale, rather than small-scale, channel fading with an abrupt transition from low PER to 100% PER. Results also show that large-scale received signal power can be modeled with a 2nd order log-distance polynomial equation on the sport court and road, but a 1st order model is sufficient for the grass field. Small-scale signal variations have been found to have a Rice distribution for signal to noise ratio levels greater than 10 dB but the Rice K-factor exhibits
Current lifestyles promote the development and advancement in wireless technologies, especially in Wireless Sensor Networks (WSN) due to its several benefits. WSN offers a low cost, low data rate, flexible routing, longer lifetime, and lowenergy consumption suitable for unmanned and long term monitoring. Among huge WSN applications, some key applications are smart houses, environmental monitoring, military applications, and other monitoring applications. As a result, ubiquitous increase in the number of wireless devices occupying the 2.4GHz frequency band. This causes a dense wireless connection followed by interference problem to WSN in the 2.4GHz frequency band. WSN is most affected by the interference issue because it has a lower data rate and transmission power compared to WLAN. Despite efforts made by researchers, to the author's knowledge, the interference issue is still a major problem in wireless networks. This paper aims to review the coexistence and interference issues of existing wireless technologies in the 2.4GHz Industrial, Scientific and Medical (ISM) band.
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