The MEFV (familial Mediterranean fever gene) researches were performed in the population of the Republic of Azerbaijan in 2016–2021. Seven mutations of the MEFV gene were identified in heterozygous, homozygous and compound homozygous conditions: R761H, M694I, M694V, V726A, R202Q, M680I and E148Q. The E148Q and R202Q mutations were discovered in exon 2 and R761H M694I, M694V, V726A, M680I were found in exon 10 in the population of the Republic of Azerbaijan. The highest gene frequency of the MEFV gene examined in 42 patients was 42.85% in the M694V mutations. The second highest frequency was the R761H and the third most frequent mutation was V726A. According to world literature, five mutations, M694V, V726A, M694I, R202Q, M680I and E148Q, constitute 75.0% of all mutations found today. In our studies, these five mutations belong to the same group, and makes up 57.6% of the total mutations found. In order to prevent hereditary disease such as the familial Mediterranean fever (FMF) in the population of the Republic of Azerbaijan, it is planned to carry out prenatal diagnosis (PND) of the at-risk families.
This paper summarises and presents the results of two-year (2020–2021) field and laboratory studies on the spread and harmfulness of bacterial canker of citrus crops (Xanthomonas citri (Hasse) Dowson.) on mid-ripening lemon cultivars (Citrus limon L.). Experimental field research conducted by us in 2020–2021. It has been established that bacterial canker (Xanthomonas citri) is found mainly on lemon bushes (Citrus limon L.). The pathogen also causes canker (Xanthomonas citri) on kinkans (Fortunella margarita (Lour) Swingle.), poncirus (Poncirus (L.) Raf.), lime (Cirtus aurantiifolia (Christm.) Swingle.). Japanese cultivars of oranges (Citrus sinensis (L.) Osbeck.) and citron (Citrus medica L.) are distinguished by significant tolerance. The most resistant are tangerines (Cirtus reticulata Blanco.) – they are almost not affected by bacterial canker (Xanthomonas citri).
We have established environmental factors that contribute to the wide spread and development of bacterial canker (Xanthomonas citri) on lemon bushes in the southern part of Azerbaijan.
The main indicators of the harmfulness of bacterial canker (Xanthomonas citri) have been identified. The potential for the death of canker-infected lemon fruits has been established. The characteristic features of external and internal signs of the disease were established. A scheme for combating bacterial canker (Xanthomonas citri) has been developed, and the optimal concentration of fungicides that retard the growth and development of pathogens has also been established. Photographs of bacterial canker (Xanthomonas citri) damage to lemon fruits are presented.
Some associations were also observed in this study andone of them, including R243X mutation and V245V polymorphism. The mean quality value of surrounding nucleotides of these variants was higher than 50 which proved their accuracy. The R261Q mutation in exon 7 was observed in seven patients from 30 patient. Studies have shown that this mutation is most common in the Azerbaijani population. Being R261G (G-A) mutation we have found a substitution of guanine with adenine. The result of mutation was on protein level, and arginine amino acid was substituted with gluthamine amino acid.
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