Remifemin is an ethanolic extract of the rhizome of Cimicifuga racemosa (C.r.) and is used to relieve climacteric hot flushes. In the present study the effects of this preparation on LH and FSH secretion of menopausal women were investigated. After an 8 weeks treatment, LH but not FSH levels were significantly reduced in patients receiving the Cimicifuga extract. To further characterize the endocrinologically active principles of this plant extract, a lipophilic extract of C.r. was prepared and subjected to Sephadex chromatography. Fractions obtained were tested for their ability to reduce LH secretion in ovariectomized (ovx) rats and to compete in vitro with 17 beta-estradiol for estrogen receptor binding sites. Three types of endocrinologically active compounds were obtained: (1) Constituents which were not ligands for the estrogen receptor but suppress LH release after chronic treatment, (2) constituents binding to the estrogen receptor and also suppressing LH release, and (3) compounds which are ligands for the estrogen receptor but without an effect of LH release. It is concluded that the LH suppressive effect of C.r. extracts observed in menopausal women and ovx rats is caused by at least three different synergistically acting compounds.
An oxepin derivative has surprisingly been detected as a constituent of a slime mold. Apart from the red dye (1), four yellow or red hydroxylated dyes are also obtained which all lack the oxepin O atom.
nen. da8 man uber systematische Fehler erst dann reden kann. wenn die Statistik in Ordnung ist. Experimental NMR Conference, Elsinore, Danemark 1977. [I011 Die sorgfaltige Wahl der Temperatur is1 kritisch. Bei zu langsamem Austausch is1 die Relaxation zu schnell, um den Magnetisierungstransfer noch anzuzeigen: bei zu hohen Ternperaturen wird die Sattigung durch schnelle Weitenvanderung auch in die anderen Positionen starker transferiert. 0 Verlag Chemie, GmbH, 0-6940 Weinheim, 1980
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