Chlorophyll (Chl) and bacteriochlorophyll (Bchl) have been made water soluble by transesterfication with serine (Ser) at the propionyl residue and tested as potential reagents for photodynamic therapy (PDT). Photocytotoxicity of the conjugates Chl-Ser and Bchl-Ser in M2R mouse melanoma was tested in cell cultures. Tissue uptake and clearance of the photosensitizers in CDI nude and C57Bl mice implanted with M2R tumors are described, Photocytotoxicity in cell cultures was determined microscopically and by [3Hlthymidine incorporation. The LD.u values in vitro were 0.05-0
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