95-raise social awareness and increase public understanding of the debilitating effects of rheumatic diseases. Every year our young association celebrates the 12th October -World Arthritis Day, as a central event in our activities calendar. In 2012, as part of the celebrations, we organized a fashion show. Objectives: To explore and promote opportunities for designing clothes for people with rheumatic and musculoskeletal diseases. Through the visual effect of the fashion show, to bring general public closer to understanding the effects of rheumatic diseases. Methods: The fashion show, themed "Move to Improve", was organized in cooperation with Belgrade Design District and Serbian Media, and was held during the 21 st Maybelline Fashion selection manifestation. The models were volunteers -RMDs sufferers from ORS, who were escorted to the stage by journalists from First Serbian Television Station. The models wore clothes that had been specifically designed to suit people who cannot get dress themselves easily. Results: Young designers did their job very well. They created simple, usable, modern clothes without small buttons, zippers, ribbons. The audience supported very kindly our brave models. The show attracted strong media attention, with reports from this event broadcast by 15 TV and 6 radio stations. Also, 17 printed media and 25 internet portals published stories about the show. Daily newspaper "Blic" organized a mini internet competition for the best fashion show during the whole fashion manifestation and more than 1.3 million visitors voted. With 62% of the votes, "Move to improve" won the prize for the best fashion show during a significant fashion manifestation in Serbia. Conclusions: Our brave volunteers have shown that, in spite of their special needs, people with RMDs can and should follow and create fashion. They were seen and admired by very many people. The "Move to Improve" show is still talked about in Serbia -among ordinary people, health professionals and RMD sufferers ... Background:Elevations of BAFF are observed in patients with SLE. Here we report renal findings from a Phase 2b clinical trial in patients with SLE treated with the subcutaneous BAFF inhibitor, blisibimod. Objectives: To evaluate the effect of 24-week therapy with blisibimod on markers of renal disease in patients with proteinuria or active inflammation. Methods: 547 patients with serologically-active SLE and SELENA SLEDAI ≥6 were randomized to receive placebo or blisibimod. 13.9% of patients had renal involvement at baseline per SELENA-SLEDAI. Proteinuria and inflammation biomarkers were evaluated throughout the study. Results: In a subgroup of subjects with baseline urinary protein equivalent to 1-6g/24hr (n=49), significantly greater reductions in proteinuria were observed with blisibimod compared to placebo from Weeks 8 through 24 (respective mean reductions of 0.73g/24hr (-35.0%) and 0.24g/24hr (-5.1%) at Week 24, p=0.045). Similarly, significantly greater reductions in proteinuria were observed in a subgroup of subjects wi...
We found that the magnesium salt of ilimaquinone, named 201-F, specifically disassembled dynamically unstable microtubules in fibroblasts and various epithelial cell lines. Unlike classical tubulin- interacting drugs such as nocodazole or colchicine which affect all classes of microtubules, 201-F did not depolymerize stable microtubules. In WIF-B–polarized hepatic cells, 201-F disrupted the Golgi complex and inhibited albumin and alpha1-antitrypsin secretion to the same extent as nocodazole. By contrast, 201-F did not impair the transport of membrane proteins to the basolateral surface, which was only affected by the total disassembly of cellular microtubules. Transcytosis of two apical membrane proteins—the alkaline phosphodiesterase B10 and dipeptidyl peptidase IV—was affected to the same extent by 201-F and nocodazole. Taken together, these results indicate that only dynamically unstable microtubules are involved in the transport of secretory proteins to the plasma membrane, and in the transcytosis of membrane proteins to the apical surface. By contrast, stable microtubules, which are not functionally affected by 201-F treatment, are involved in the transport of membrane proteins to the basolateral surface. By specifically disassembling highly dynamic microtubules, 201-F is an invaluable tool with which to study the functional specialization of stable and dynamic microtubules in living cells.
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