The era of rapid growth of the internet has witnessed the exponential growth of electronic payment systems (EPS); consequently, business transactions are constantly shifting from cash-based to electronic-based system. This paper is a product of a research conducted to explore factors that could influence effective adoption and implementation of the EPS among hospitals in Tanzania and the challenges associated with its adoption. The study used the KCMC as a case in point. The case study design was used. In this study we sampled 152 respondents randomly who included clients at the outpatient clinics of the hospital. The data were gathered using a structured questionnaire consistent with the Technology Acceptance Model (TAM). The findings suggest that the majority of the clients preferred to use EPS whereas, intention to use EPS, previous experience in the use of EPS, and being banked were significant factors influencing both preference of EPS and intention to use EPS. It is recommended that in order to hasten adoption of EPS in Tanzania it is important to address the identified barriers and also to encourage clients to keep their money in and use the services of banks.
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