Objective:To describe a case of documented serum sickness in a dog following administration of a single dose of a novel antivenin crotalidae polyvalent. Case Summary:A 4-year-old female neutered mixed breed dog developed recurrent signs of hypersensitivity (swelling, edema, urticaria/hives, gastrointestinal signs, vasculitis) at 1 and 2 weeks following administration of a single unit of a novel antivenin crotalidae polyvalent plasma product. Both episodes were treated with antihistamines and glucocorticoids and signs improved rapidly, with a prolonged course of glucocorticoids and antihistamines administered following the second occurrence. Diagnosis of serum sickness was based on clinical appearance of delayed hypersensitivity following exposure to novel biologic product, absence of other inciting cause of hypersensitivity, complement testing, and skin biopsies confirming vasculitis. New or Unique Information Provided:This case documents the first report of delayed hypersensitivity with a novel antivenin plasma product. This is the only case report of serum sickness to a single unit of antivenin. Additionally, the dog developed recurrence of hypersensitivity following the initial episode at 1 week; appropriate identification and prolonged treatment could have prevented recurrence and additional hospitalization. Cost and benefit analysis should be considered with antivenin administration. K E Y W O R D Sanatomy, anesthesiology, cardiovascular, coagulation, fluid balance

ObjectiveTo report the development of a tension pneumomediastinum during mechanical ventilation of a young Irish Wolfhound with aspiration pneumonia.Case SummaryA 9‐month‐old intact female Irish Wolfhound was presented for clinical signs consistent with aspiration pneumonia. Evaluation of her pedigree and clinical signs prompted suspicion of Irish Wolfhound rhinitis bronchopneumonia syndrome as a contributing factor. Despite supportive care for bronchopneumonia, progressive hypoxemia and increased work of breathing required mechanical ventilation (MV). Development of a pneumothorax 36 hours after initiation of MV necessitated bilateral thoracostomy tubes. Cardiovascular decline persisted despite resolution of the pneumothorax and 1 hour later the dog was humanely euthanized. On necropsy, severe pneumomediastinum was identified without other evidence of barotrauma. Necropsy results suggested tension pneumomediastinum as the cause of pneumothorax and cardiovascular deterioration.New or Unique Information ProvidedPneumomediastinum has not been described in dogs receiving MV. This case highlights the importance of rapid detection of pneumomediastinum during MV, as the complication can quickly become life‐threatening.

To report the incidence and type of peripheral intravenous catheter complications in hospitalised dogs.MethOds: A prospective, observational trial was performed. Peripheral intravenous catheters were monitored for complications. Complications were documented and classified as extravasation, phlebitis, dislodgement, occlusion and line breakage. If phlebitis was present, the Visual Infusion Phlebitis Scale was used to assign a grade (0 to 5). Fisher's exact test was used to compare the type of complications between the critical care unit and the intermediate care unit. A univariate logistic model was used to compare the incidence of complications between the critical care unit and the intermediate care unit and adjusted odds ratios were used to compare the groups.Results: The incidence of peripheral intravenous catheter complications was 24.2% in the Critical Care Unit and 13.1% in the Intermediate Care Unit, with an overall incidence of 19.9%. Phlebitis was the most common peripheral intravenous catheter complication in the Critical Care Unit, and line breakage was the most common complication in the Intermediate Care Unit. Length of hospitalisation and weight had a significant effect on the likelihood of complication. In a multivariable logistic regression model, the odds of a peripheral intravenous catheter complication was not significantly higher in CCU than IMCU, accounting for length of hospitalisation and weight (adjusted odds ratio, 1.84; 95% confidence interval, 0.98 to 3.48).clinical significance: Peripheral intravenous catheter complications are common in hospitalised dogs and may result in an increased expense for owners, failure to deliver prescribed treatments, venous depletion (lack of peripheral vessels for intravenous catheter placement) and pain experienced by the patient. Techniques to reduce peripheral intravenous catheter complications should be further evaluated and may include the use of peripheral intravenous catheter placement and maintenance checklists, use of force-activated separation devices, or patient sedation.

Objective To determine the success rate and complications associated with inducing emesis in dogs that have ingested foreign material. Design Retrospective case series, 2010–2014. Setting Private practice and referral center. Animals Sixty‐one client‐owned dogs that had emesis induced for the treatment of ingestion of foreign material. Interventions None. Measurements and Main Results Emesis was successfully induced in 59 of 61 (97%) dogs administered an emetic. Of those 59 dogs, 46 (78%) produced the foreign body. There were no complications reported in any of the dogs in which emesis was successfully induced. Dogs in which emesis was successfully induced were likely to produce the foreign body (P = 0.01). Conclusion Based on the results of this study, emesis appears to be a safe and effective means for the removal of certain gastric foreign bodies in dogs.

OBJECTIVE To determine whether shock index (SI) positively correlates with percentage blood loss and negatively correlates with cardiac output (CO) in a canine hemorrhagic shock model and whether SI and metabolic markers may be used as end point targets for resuscitation. ANIMALS 8 healthy Beagles. PROCEDURES Between September and December 2021, dogs underwent general anesthesia for experimental induction of hypotensive shock, with the total volume of blood removed, CO, heart rate, systolic blood pressure, base excess, blood pH, and concentrations of hemoglobin, lactate, ionized calcium recorded, and SI calculated at 4 time points (TPs): after anesthetic induction when the dog had been stable for 10 minutes (TP1), 10 minutes after the mean arterial pressure stabilized to a target of 40 mm Hg following jugular removal of up to 60% blood volume to induce hemorrhagic shock (TP2), 10 minutes after autotransfusion of 50% of the removed blood (TP3), and 10 minutes after autotransfusion of the remaining 50% of the removed blood (TP4). RESULTS Mean SI increased between TP1 (1.08 ± 0.35) and TP2 (1.90 ± 0.73) and did not return to the prehemorrhage values for TP3 or TP4. SI correlated positively with percentage blood loss (r = 0.583) and negatively with CO (r = –0.543). CLINICAL RELEVANCE An increase in SI may support diagnosis of hemorrhagic shock; however, SI cannot be used as the sole end point of resuscitation. Significant differences in blood pH, base excess, and lactate concentration suggested they may be useful markers of hemorrhagic shock and need for blood transfusion.