The aim: Evaluate clinical and laboratory parameters of the patients with type 2 diabetes mellitus and concomitant obesity after a course of dapagliflozin treatment and
compare with a standard treatment regimen.
Materials and methods: Conducted a comprehensive clinical laboratory examination and measurement of the anthropometric parameters of the patients with type 2 diabetes
mellitus and concomitant obesity, with subsequent statistical calculations.
Results: The data obtained at different stages of the study revealed a statistically significant effect of glucose treatment and glycosylated hemoglobin (HbA1c). Since the 6th
month of dapagliflozin treatment, we have shown a tendency to lose weight compared to baseline in this group of patients and controls.
Conclusions: Type 2 diabetes mellitus and obesity significantly increase the risk of developing a number of complications. Complex control and effects on clinical laboratory
and anthropometric parameters can statistically significantly influence the development of the complications, and in this context, dapaglifloflozin showed statistically better
results than standard metformin monotherapy.
We investigated children with primary arterial hypertension (PAH) from the Transcarpathian region of Ukraine (68 children, middle age 14.68 ± 0.84 years). In patients with arterial hypertension which PAH debuted in adolescence and have changes in lipid profile are formed pathological process in two ways: first way presented increase in total cholesterol associated with lower high-density lipoprotein (HDL) cholesterol indicators, and other is an increase in triglycerides with decreased levels of HDL cholesterol, according to data of M.M. Korenev et al. (2010, 2011). These changes in lipid profile is prognostically unfavorable signs of atherosclerosis which developed in the patients (1st way), in others — development of the metabolic syndrome in the young age (14–15 years), which we observed in our research. Our data are also relevant tendency. In children with PAH increase triglyceride levels (1.96 ± 0.04 mmol/l) associated with significant decrease in HDL cholesterol fraction (1.20 ± 0.31 mmol/l) which predicts development of the metabolic syndrome in the young age.
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