BACKGROUNDAtherosclerosis of coronary arteries may manifest as myocardial infarction and angina pectoris and that of central nervous system as non-haemorrhagic cerebrovascular accidents and transient ischaemic attacks.The objective of this study is to compare the efficacy of atorvastatin and rosuvastatin on various aspects of lipid profile, viz. serum total cholesterol, serum LDL-C, serum VLDL-C, serum HDL-C and serum triglycerides in Indian patients having dyslipidaemia in this part of country. MATERIALS AND METHODSThis was a randomised open study conducted on patients with abnormal lipid profile attending the OPD/ wards of Department of Medicine, Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar in the year 2006. Based on our previous year OPD and indoor patients' records, the total number of patients with dyslipidaemia was 165. Thinking that 100 patients would be achievable within 1 year, so a total of 100 patients were included in the study and the patients were divided randomly by lottery method into two groups of 50 patients each, Group A was put on Atorvastatin 20 mg daily and Group B was put on Rosuvastatin 20 mg daily. Out of total 100 patients, 50 (50%) were males and 50 (50%) were females. In Group A and B, there were 25 (50%) males and 25 (50%) females each. Lipid profiles were recorded in every patient at 0, 6 weeks and then 12 weeks. RESULTSThis was a randomised open study conducted on patients with abnormal lipid profile attending the OPD/ wards of Department of Medicine, Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar in the year 2006. Based on our previous year OPD and indoor patients' records, the total number of patients with dyslipidaemia was 165. Thinking that 100 patients would be achievable within 1 year so a total of 100 patients were included in the study and the patients were divided randomly by lottery method into two groups of 50 patients each; Group A was put on Atorvastatin 20 mg daily and Group B was put on Rosuvastatin 20 mg daily. Out of total 100 patients, 50 (50%) were males and 50 (50%) were females. In Group A and B, there were 25 (50%) males and 25 (50%) females each. Lipid profiles were recorded in every patient at 0, 6 weeks and then 12 weeks. CONCLUSIONRosuvastatin lowers total serum cholesterol, serum LDL-C, serum TG and raises serum HDL-C more significantly as compared to Atorvastatin.
BACKGROUNDThe objective of this study is to assess the association between serum uric acid and risk of stroke incidence and mortality along with its correlation with other risk factors, because hyperuricaemia is hypothesised to be a risk factor for stroke, but to date results from observational studies are conflicting. MATERIALS AND METHODSThis prospective study was conducted on 60 patients of acute ischaemic stroke diagnosed on CT scan, admitted in Guru Nanak Dev Hospital attached to Govt. Medical College, Amritsar. Two groups were formed on the basis of serum uric acid levels and they are compared with respect to occurrence of stroke, risk factors and the prognosis at 1-month interval.
BACKGROUNDThe word cirrhosis comes from the Greek word kirrhos, which means orange yellow. 1 Cirrhosis is a chronic disease of the liver in which diffuse destruction and regeneration of hepatic parenchymal cells and diffuse increase in connective tissue has resulted in disorganisation of the lobular architecture, which leads to various complications such as portal hypertension and its sequelae including gastro-oesophageal varices and splenomegaly, thrombocytopaenia, etc.The aim of this study is to study the correlation of portal vein diameter, splenomegaly and thrombocytopaenia with gastrooesophageal varices in cirrhotic patients.
Background: Nervous system involvement is one of the catastrophic target of human immunodeficiency virus (HIV) infection.
Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher (up to 50%) in alcoholic patients than in the general population. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. In Our study on 194 patients of ALD, we found anti Hcv ab was positive in 18.6% of patients of ALD. Most of cases had developed cirrhosis and its complications. Of all Anti HCV Ab positive patients 55.6% presented with Gastrointestinal bleeding and 46.7% with Hepatic encephalopathy. The mean value of SGOT and SGPT were significantly higher in Anti HCV Ab positive patients as compared to Anti Hcv ab negative patients. The study concluded that alcoholics who are Anti HCV Ab positive are more prone to develop cirrhosis of liver with its various complication
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