Introduction: Coronavirus-19 (COVID-19) pandemic is evolving rapidly worldwide. It has led to a worldwide research to identify the people who are at more risk for developing the infection, increasing severity and mortality. Aim: The aim of this systematic review was to evaluate the risk of some of the common and major comorbidities on the outcome of the disease. Materials and Methods: A literature search was conducted using EMBASE, PUBMED, Web of science, SCOPUS and Cochrane database. Medical Subject Headings (MeSH) used were “COVID-19” or “SARS CoV 2” or “Coronavirus disease 19” and “Comorbidities” or “Risk factors”. Individual risk factors were also used as keywords such as “Diabetes”, Hypertension”, “Obesity”, “Chronic kidney disease”, “Elderly”, “Cardiovascular disease”, “Lung disorders” and “Malignancy”. Two researchers conducted the search independently. Results: After extensive search, 57 articles were shortlisted for complete review. It was found that patients with comorbidities had more severe disease than those without comorbidities. Patients with more number of comorbidities had more severe disease than patients with single comorbidity. Initial reports suggested that elderly were at more risk than the younger population. The most common comorbidity was hypertension followed by diabetes and obesity. Conclusion: A meticulous triage of patients should be carried out after acquiring proper medical history because this will help to identify patients who are at an increased risk of poor outcome of the infection. Also, they should be given more aggressive treatment upon diagnosis of infection.

As Coronavirus disease 2019 (COVID 19) is declared a global pandemic. Management of expecting mothers and newborn care becomes a great challenge to the physicians and their family. They should follow same guidelines as the general population to avoid exposure to the virus as much as possible. Pregnancy does not seem to increase the risk of infection nor accelerate its natural history or the severity of illness. Routine prenatal-antenatal care should be home monitored and tele-medicine encouraged as much as possible. Women with comorbidities or at high risk of infection such as recent history of travel, from a containment zone, history of primary or secondary contact should be closely monitored for symptoms. RT PCR is recommended prior to labour or one day prior to elective surgery. Supportive treatment is important in infected patients. Low molecular weight heparin can be used for thromboprophylaxis in severe illness. Data on use of Remdesivir, hydroxychloroquine, Lopinavir-Ritonavir are limited. There is limited data on placental transmission of the virus. Newborn should also be immediately be tested following delivery of a COVID19 pregnant women. If newborn is found to be negative, strict hygienic measures according to CDC should be followed to express breast milk. According to WHO, breast milk banks are a safe alternative. Few mothers may prefer to give formula feeds, which can be administered by healthy care givers. There is limited data regarding transmission of virus through breast milk.