The effects of molecular diffusivities of heat and mass on the counter-gradient scalar and momentum transfer in strongly stable stratification are experimentally investigated in unsheared and sheared stratified water mixing-layer flows downstream of turbulence-generating grids. Experiments are carried out in two kinds of stably stratified water flows. In the case of thermal stratification, the difference between the turbulent fluxes of an active scalar (heat with the Prandtl number of Pr ≈ 6) and a passive scalar (mass with the Schmidt number of Sc ≈ 600) is investigated. In the case of salt stratification, the effects of the molecular diffusion of the active scalar (salt) with a very high Schmidt number of Sc ≈ 600 on the counter-gradient scalar transfer is studied. Comparisons of the effects of molecular diffusivities are also made between thermally stratified water and air (Pr ≈ 0.7) flows. Further, the effects of mean shear on the counter-gradient scalar and momentum transfer are investigated for both stratified cases. Instantaneous temperature, concentration and streamwise and vertical velocities are simultaneously measured using a combined technique with a resistance thermometer, a laser-induced fluorescence method, and a laser-Doppler velocimeter with high spatial resolution. Turbulent scalar fluxes, joint probability density functions, and cospectra are estimated.The results of the first case show that both active heat and passive mass develop counter-gradient fluxes but that the counter-gradient flux of passive mass is about 10% larger than that of active heat, mostly due to molecular diffusion effects at small scales. The counter-gradient scalar transfer mechanism in stable stratification can be explained by considering the relative balance between the available potential energy and the turbulent kinetic energy as in Schumann (1987). In thermally and salt-stratified water mixing-layer flows with the active scalars of high Prandtl and Schmidt numbers, the buoyancy-induced motions with finger-like structures first contribute to the counter-gradient scalar fluxes at small scales, and then the large-scale motions, which bring fluid back to its original levels, generate the counter-gradient fluxes at large scales. The contribution of the small-scale motions to the counter-gradient fluxes in stratified water flows is quite different from that in stratified air flows. The higher Prandtl or Schmidt number of the active scalar generates both the stronger buoyancy effects and the longer time-oscillation period of the counter-gradient scalar fluxes. The time-oscillation occurs at large scales but the counter-gradient fluxes at small scales persist without oscillating. The mean shear acts to reduce the counter-gradient scalar and momentum transfer at large scales, and therefore the counter-gradient fluxes in sheared stratified flows can be seen only in very strong stratification. The behaviour of the counter-gradient momentum flux in strong stratification is quite similar to that of the counter-gradient scalar flux.
Recent improvements in perinatal management have improved the prognosis in patients with severe congenital diaphragmatic hernia (CDH). However, in surviving patients with severe CDH, hearing loss has sometimes been reported to occur during the follow-up period. Although some of the risk factors for developing sensorineural hearing loss (SNHL) have been reported in CDH, no definitive risk factors have yet been reported. We, therefore, investigated the risk factors regarding postnatal management in patients with severe CDH. In 16 surviving patients with severe CDH, which had all been detected antenatally, and whose lung-to-thoracic ratio was less than 0.2, four patients demonstrated late onset SNHL, which occurred between 1.5 and 5 years of age. The risk factors for SNHL regarding the postnatal treatment for CDH were analyzed between the four patients with SNHL and the remaining 12 patients without SNHL, regarding such factors as the use of ototoxic drugs, neuromuscular blocking agents, high-frequency oscillation (HFO), and inhaled nitric oxide, the duration of hypocapnia, hypoxia, severe acidosis, severe alkalosis, and mechanical ventilation. In addition, the types of neuromuscular blocking agents were also analyzed, including the administration of pancuronium bromide (PB) and vecuronium bromide (VB). The patients with SNHL were found to have a significantly higher risk than the patients without SNHL regarding the duration of loop diuretics usage and the duration of usage of both mechanical ventilation and HFO. Furthermore, all four patients with SNHL used PB. In contrast, none of the five patients using VB developed SNHL The duration and cumulative dose of PB used in the patients with severe CDH showed a significant correlation to the occurrence of SNHL. Although this study was retrospective, based on our data, the prolonged use of PB, in addition to the duration of treatment by loop diuretics, mechanical ventilation, and HFO usage, might, thus, be suggested to be a possible risk factor for late onset SNHL in patients with severe CDH.
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