Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal computed tomography angiography cases. The model has good tolerance to image quality and is tested with different manufacturers. Simulated real-world studies are conducted in consecutive internal and external cohorts, in which it achieves an improved patient-level sensitivity and lesion-level sensitivity compared to that of radiologists and expert neurosurgeons. A specific cohort of suspected acute ischemic stroke is employed and it is found that 99.0% predicted-negative cases can be trusted with high confidence, leading to a potential reduction in human workload. A prospective study is warranted to determine whether the algorithm could improve patients’ care in comparison to clinicians’ assessment.

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Importance. With the booming growth of artificial intelligence (AI), especially the recent advancements of deep learning, utilizing advanced deep learning-based methods for medical image analysis has become an active research area both in medical industry and academia. This paper reviewed the recent progress of deep learning research in medical image analysis and clinical applications. It also discussed the existing problems in the field and provided possible solutions and future directions. Highlights. This paper reviewed the advancement of convolutional neural network-based techniques in clinical applications. More specifically, state-of-the-art clinical applications include four major human body systems: the nervous system, the cardiovascular system, the digestive system, and the skeletal system. Overall, according to the best available evidence, deep learning models performed well in medical image analysis, but what cannot be ignored are the algorithms derived from small-scale medical datasets impeding the clinical applicability. Future direction could include federated learning, benchmark dataset collection, and utilizing domain subject knowledge as priors. Conclusion. Recent advanced deep learning technologies have achieved great success in medical image analysis with high accuracy, efficiency, stability, and scalability. Technological advancements that can alleviate the high demands on high-quality large-scale datasets could be one of the future developments in this area.

Attributes are mid-level semantic properties of objects. Recent research has shown that visual attributes can benefit many traditional learning problems in computer vision community. However, attribute learning is still a challenging problem as the attributes may not always be predictable directly from input images and the variation of visual attributes is sometimes large across categories. In this paper, we propose a unified multiplicative framework for attribute learning, which tackles the key problems. Specifically, images and category information are jointly projected into a shared feature space, where the latent factors are disentangled and multiplied for attribute prediction. The resulting attribute classifier is category-specific instead of being shared by all categories. Moreover, our method can leverage auxiliary data to enhance the predictive ability of attribute classifiers, reducing the effort of instance-level attribute annotation to some extent. Experimental results show that our method achieves superior performance on both instance-level and category-level attribute prediction. For zero-shot learning based on attributes, our method significantly improves the state-of-theart performance on AwA dataset and achieves comparable performance on CUB dataset.