Background: The addition of Magnesium sulphate (MgSO4) to postoperative Fentanyl Epidural infusions has been demonstrated to reduce the requirement for Fentanyl. Methodology: Group I (38 patients) got Epidural Fentanyl 50 mg (1 cc) diluted and made up to 6 cc with normal saline, whereas Group II (38 patients) received Epidural Fentanyl 50 μg (1 cc) + MgSO4 50 mg (4 units in insulin syringe of 50% solution) diluted and made up to 6 cc with normal saline. The effects of analgesia on pulse rate and blood pressure were measured as well as the duration of analgesia. Results: In this study, an average age of the study population was 41.25 ± 3.25 years in Group I and 42.14 ± 4.42 years in Group II. The pulse rate in Group-I increased significantly from 105 minutes compared to Group-II, whereas it remained steady in Group-II throughout the research duration. Systolic BP increased significantly in Group-I after 90 minutes compared to Group-II, but remained steady in Group-II. SPO2 and respiratory rates did not differ significantly.Conclusion: Adding magnesium sulphate to fentanyl in epidural analgesia increased the duration of analgesia while maintaining hemodynamic stability.
Background: Spinal anesthesia is commonly administered intraoperatively. However, relative short duration of action is associated with local anesthetics. A variety of adjuvants is used for prolongation of postoperative analgesia. Aims and Objectives: Comparative analysis of intravenous dexmedetomidine as a premedication and spinal anesthesia treatment with intrathecal isobaric ropivacain of 0.75% in elective lower limb surgery and lower abdominal surgery. Material and Methods: Following approval by the ethical committee, 60 patients scheduled for elective lower limb orthopedic surgery and lower abdominal surgery were chosen and randomized into two groups (n=30). The patient was then intrathecally administered 3 ml amount of 0.75 percent isobaric ropivacaine in lateral location. Another syringe containing dexmedetomidine was given after 10 minutes of placement, for 10 minutes using syringe pump. Comparison of sensory block initiation, analgesic effects and hemodynamic effects was made between the 2 classes. Results: Comparison of age distribution of (P=0.164) was not statistically important. In Group P, the median age was (40.96 ± 15.3 years) and in Group S (44.33 ± 12.66 years).
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