Anaesthesia of multiple drug allergic patients may be very challenging. Especially with a patient showing allergic signs for multiple main anaesthesia drugs and scheduled for laparoscopic robot-assisted surgery. We report the case of a 65-year-old man. The systemic allergic screenings concluded with rocuronium, atracurium, cisatracurium, propofol, chlorhexidine, latex and betalactamine contraindications. Sufentanil to be used with extreme precautions. General anaesthesia was performed with an OFA protocol. Muscle relaxation was obtained by deep sedation. A close collaboration with the surgeons made it possible to carry out the procedure with a perfect control of the postoperative pain.