Organo-phosphorus compounds S 0080 A Simple and Convenient Procedure for the Synthesis of 1-Aminophosphonates from Aromatic Aldehydes. -A simple and potentially scalable process for the synthesis of 1-aminophosphonates from aromatic aldehydes, aqueous ammonia and diethyl phosphite is reported. -(KABOUDIN*, B.; MORADI, K.; Tetrahedron Lett. 46 (2005) 17, 2989-2991; Dep. Chem., Inst. Adv. Stud. Basic Sci., Gava Zang, Zanjan 45195, Iran; Eng.) -Mais 34-234
A convenient preparative approach for the synthesis of bis[1-diethoxyphosphorylalkyl]amines has been developed. Treatment of aromatic aldehydes with ammonia and reaction with diethyl phosphite gives diethyl aryl[(arylmethylidene)amino]methylphosphonates, which can be easily reacted with diethyl phosphite in the presence of chlorotrimethylsilane to give bis[1-diethoxyphosphorylalkyl]amines. This method is easy, rapid, and good-yielding for the synthesis of bis[1-diethoxyphosphorylalkyl]amines from simple starting materials.
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