AIM: To evaluate iodine status in the population of Western Kazakhstan on the example of the Aktobe region according to data of urinary iodine concentrations. There were examined 2257 children aged from 7 to 12 years. Urinary iodine was carried out in 10% of schoolchildren by semiquantitative method under field conditions. According to the 30-cluster survey the prevalence of goiter in the region amounted to 42.71 ± 1,04%. The proportion of children with optimal urinary iodine concentrations is only 12.8%, more than 300 mcg/l - 57.82% of the children, more than 400 mcg/l was determined in 25.12% of the children. The high prevalence of goiter against the background of high rates of urinary iodine suggests the impact of other goitrogenic factors in the region.
Relevance: Immunophenotyping with multiparameter flow cytofluorimetry differentiates classical variants of chronic B-lymphoproliferative diseases. However, some atypical conditions are hard to interpret, leading to the search for new differential markers. The study aimed to analyze the predictive value of monoclonal markers CD200, CD103, and CD11c in differential diagnostics of hairy cell leukemia, splenic marginal zone lymphoma, and splenic mantle zone lymphoma. Methods: We studied open access articles with a search depth of 10 years using the following databases of scientific publications and specialized search engines: PubMed, Google Scholar, Cochrane Library, Web of Science, Scopus, Сyberleninka, and the eLIBRARY electronic library. As a result, 30 literary sources were identified, of which eight publications were the basis of the analytical material for this article. Inclusion criteria: Evidence level A, B publications: meta-analyses, systematic reviews, cohort, and cross-sectional studies. Exclusion criteria: expert opinion in the form of short messages or promotional articles. Results: We revealed a different degree of informativeness of some traditional markers in immunophenotypic diagnostics of B-cell lymphoproliferative diseases by flow cytometry; the use of additional differential markers CD200, CD103, and CD11c showed their high informativeness in differential diagnostics between different variants of B-cell lymphoproliferative diseases with initial immunophenotypic and morphological characteristics of lymphoid elements. Conclusion: Analysis of the selected publications gives grounds to improve the multiparametric panel for differential diagnostics of chronic B-lymphoproliferative diseases.
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