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Introduction Fast population aging is a global reality. Today’s major challenge is to promote the healthy aging of more and more people by acting on factors that can be modified, such as physical exercise. Regular exercise could contribute to the prevention of chronic diseases associated with aging. Research has been conducted on the physical training response of elderly individuals, but there is not yet any consensus on the influence of strength training or IL-6 polymorphism on levels of inflammatory markers such as IL-6 and muscle damage marker CK, particularly in healthy elderly male individuals. Objectives The aim of this study was to evaluate the relationship of IL-6 promoter -174 C/G gene polymorphism on systemic IL-6 responses and muscle damage after eccentric strength training in elderly men. Methods This is a prospective, high-quality study. Gene frequency of polymorphism of promoter gene IL6 G-174C was identified using the Hardy-Weinberg test in 28 older male volunteers. The relationships of each genotype with IL-6 and CK serum levels were analyzed. CK and IL-6 levels were determined at pre-training and 0h, 3h, 24h, and 48h post-training periods. Results Differences in baseline and post-training IL-6 levels of genotypic groups were observed for all time periods analyzed (p = 0.029). Eccentric exercise efficiently reduced post-intervention muscle damage, thus showing a statistical difference between the pre- and post-intervention time points ( p = <0.0005). Conclusion Eccentric training influenced CK and IL-6 modulation independently of the polymorphism of the IL-6 promoter gene -174 C/G. Level of evidence II, Prospective comparative type.

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Background In front of the physical and social isolation, as well as feelings of fear and instability imposed by the pandemic of COVID-19, especially for risk groups such as people 50 + , it became even more relevant to discuss the formulation of personal plans for this age population. This study aimed to analyse the individual plans of people 50 + , considering their perception, feelings and life experiences during the COVID-19 pandemic. Methods This is a mixed study (quali-quantitative), using Minayo’s methodology for content analysis and frequency analyses, made with 39 participants from the University of Brasília Educational Program, Universidade do Envelhecer – UniSER/UnB. We used a word cloud system and a wheel of life tool to showcase the results. Results Analysing professional achievements and situations participants want to overcome, the categories of feelings that stand out were Loving Relationships, Sadness, Family Absence, Grief, Trauma and Regret. Intellectual Development, Personal Fulfilment, Purpose and Creativity, Hobbies and Fun were the most mentioned personal plans displayed by the wheel of life. The key personal changes mentioned were to be less shy, prioritise themselves, change how they interact with others, and focus on their health. Conclusions This study concludes that perception, feelings and life experiences during the COVID-19 pandemic did not seem to directly affect the path in elaborating personal plans.

Objetivo: Caracterizar o perfil de hemofílicos vinculados a uma associação de pacientes em Brasília - DF, Brasil. Método: Pesquisa transversal com amostragem por conveniência, realizada com 49 hemofílicos adultos, do sexo masculino, vinculados à Associação dos Voluntários, Pesquisadores e Portadores de Coagulopatias (AJUDE-C). O estudo foi aprovado pelo Comitê de Ética em Pesquisas com Seres Humanos. Através de um formulário foi coletado informações sociodemográficas e clínicas. A normalidade dos dados foi avaliada através do teste de Shapiro-Wilk. Resultados: Avaliaram-se 49 hemofílicos adultos com média de idade 37 ±8,4 anos, estando 43% na faixa etária de 30-39 anos. Predominou a raça/cor parda (49%), estado civil solteiro (61%), em atividade laboral (57%) e 53% residiam a menos de 30 Km do local de tratamento. Clinicamente, predominou a hemofilia A (79,6%), doença grave (77,6%) e o uso de profilaxia secundária (75,5%). Conclusão: Maior parte da amostra exerce atividade laboral. Esse fato pode ser explicado pela administração da profilaxia secundária e proximidade entre a residência/local de tratamento, mantendo os fatores de coagulação em níveis seguros, e dando capacidade de rápido atendimento em casos emergenciais, gerando maior autonomia nessa população. Descritores: Hemofilia; Distúrbio de coagulação; Profilaxia.