The performance of the discriminant function is degraded if the parameters used contain estimation errors. A peaking phenomenon is known in which the classification rate reaches the maximum for a certain feature dimension, but decreases with the further increase of the feature dimension. This paper reports the result of experimental examination of the relations of the classification rates of the Euclid distance, the quadratic discriminant function [1] to the feature dimension. It is shown that the modified quadratic discriminant function corresponds to the discriminant function where the maximum‐likelihood estimation for the covariance matrix of the quadratic discriminant function is replaced by a kind of pseudo‐Bayes estimation, and suppresses the peaking phenomenon.
Summary
In order to investigate the influence of Antihistaminica (AH) upon ISD, experiments were made in ten series upon seven subject.;, where each subject received 25 r of LSD orally and afterward 15–45 mg. of AH interavenously in slow injection.
The results obtained are as follows: In all cases, accentuation of the LSD symptoms took place; in two cases of 15 mg. AH. accentuation stayed slight, the duration short and the effect insufficient, contrasted with seven cases of 30 mg. AH with conspicuous accentuation with duration over 80 minutes in average. The said dose must be appropriate for the purpose. And in another case administered with 45 mg., there appeared findings speaking for an over‐dose, it is well assumable that AH effect is expressed always proportionate to its dose.
AH effect is manifested most remarkably in the acme of the LSD symptoms; that effect gets rapidly weakened with decrease of the action of LSD speaking in itself that AH works intensifying the LSD action but little prolonging the course of the action.
In a control case administered with AH alone, it was found that the symptoms of accentuation above mentioned bear in within such symptoms proper to AH, itself constituting portion of AH effect in question. It is clear that the accentuation is a thing of higher order than sheer summation of symptoms of both drugs. As a side‐proof of the above in two cases of subsequent Histamine administration against once accentuated LSD symptoms through AH, a marked alleviation of the symptoms was realized, too.
All in all, the authors are of the opinion that the AH effect is produced by the inhibitory action of its own against normally pre‐existent Histamine portion.
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