Developing interventions to reduce sedentary behavior in the workplace is an important public health priority. Furthermore, research is needed to determine whether different approaches to breaking up prolonged sitting during the workday are equally feasible and effective. Thus, the purpose of this study was to determine whether varying the frequency and duration of activity breaks during the workday would differentially impact sedentary behavior and health outcomes. Inactive females (N = 49) working full-time sedentary jobs were recruited for this parallel-group randomized trial. Participants were randomly assigned to take short, frequent breaks from sitting (1–2 min every half hour; SB) or longer, planned breaks from sitting (two 15-minute breaks per workday; LB) during each workday across an 8-week intervention. Sedentary time and health outcomes were assessed at baseline and post-intervention. The study ran from March 2014–June 2015. Results showed sedentary time during the workday decreased significantly in the SB group (− 35.6 min; d = − 0.75; p = 0.03), but did not change in the LB group (+ 4.5 min; d = 0.12). Participants in the SB group also demonstrated small-to-moderate declines in total cholesterol (d = − 0.33; p = 0.10), triglycerides (d = − 0.38; p = 0.06) and fasting blood glucose (d = − 0.29; p = 0.01) from pre to post-intervention. Health outcomes did not change in the LB group. This study demonstrated that taking short, frequent breaks from sitting during the workday is a feasible and effective approach for reducing sedentary time at work. These results have implications for the development of public health messages addressing sedentary behavior, and inform future interventions to reduce sedentary time in the workplace.Trial registrationThis study is registered at www.clinicaltrials.gov: NCT02609438.
Both physical activity status and aging appear to affect the postprandial metabolic, namely TG, response to a high-fat meal. These findings point to an inherently diminished metabolic capacity with aging, but suggest that physical activity may help minimize this decrement.
This study suggests that taking short, frequent breaks from sitting may be an effective strategy for improving affective outcomes among sedentary female employees.
Case summary An 8-year-old female spayed domestic shorthair cat was presented for evaluation of non-specific lethargy and pain. It was diagnosed with septic shock secondary to wounds on the dorsum and required treatment with multiple vasopressors for circulatory support. During the course of hospitalization, it was weaned from vasopressors but subsequently developed symmetric skin necrosis and sloughing of the paws on the right thoracic and right pelvic limbs leading to a presumptive diagnosis of suspected symmetrical peripheral gangrene (SPG). Relevance and novel information This report documents the first case of suspected SPG in a cat that received multiple vasopressors for treatment of septic shock. Early recognition, cessation of vasopressor therapy and surgical management are necessary for treatment of this condition.
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