The Omicron variant that caused a huge surge in COVID-19 infections worldwide has been studied in terms of prevalence, infectivity, and virulency. The first study conducted in South Africa showed the low pathogenic nature of the Omicron variant compared to the Delta and original Wuhan variants. The deaths, ICU admissions, length of the hospital stay, and also the need of oxygen support all reduced greatly in Omicron infected patients as compared to the earlier variants. The share of the Omicron variant in Delhi (India) rose rapidly. In two weeks (December 21, 2021-January 3, 2022), the omicron prevalence increased from 38% to 81%. Because of the Omicron variant, in the last week of January 2022, Delhi’s caseload surged nine folds. The cases analysed in Delhi, Mumbai, and throughout India revealed that the number of deaths during the Omicron wave was much lower compared to the Delta and Wuhan variants.
The dynamics of the Omicron variant in India, Mumbai, and Delhi have been studied. The % share of the Omicron variant in overall India rose from 0.35% to 97.12% during the period November 29, 2021, to February 7, 2022. Due to the emergence of the Omicron variant, the daily new infections in India rose from a baseline tally of below 8,000 cases to the highest number of 347,063 cases recorded on January 20, 2022. In Mumbai, the Omicron variant completely replaced the Delta and other lineages as reported on March 3, 2022 genome sequencing report. In Mumbai because of the Omicron variant surge, the new infections rose to 20,971 on January 7, 2022, from a baseline tally of 191 daily cases recorded after receding the second Delta variant wave. In real-time, the vaccine effectiveness among the Indian population during the Omicron variant surge was studied and noticed that the two-dose regimen was 99.3% effective in preventing death. The death rate among the hospitalized patients was reduced by 12% among the vaccinated individuals compared to the unvaccinated ones. During the Omicron variant wave, the average age of the COVID-19 patients shifted by 11 years towards the younger age which was because the vaccination among the younger population was low compared to the elderly population.
SummaryThe complexation of xylazine with β-cyclodextrin was studied in aqueous medium. 1H NMR titrations confirmed the formation of a 1:1 inclusion complex. A ROESY spectrum was recorded with long mixing time which contained TOCSY artifacts. It only confirmed the presence of xylazine aromatic ring in the β-cyclodextrin cavity. No information regarding the mode of penetration, from the wide or narrow side, could be obtained. We calculated the peak intensity ratio from the inter-proton distances for the most stable conformations obtained by molecular dynamics studies in vacuum. The results show that highly accurate structural information can be deduced efficiently by the combined use of quantitative ROESY and molecular dynamics analysis. On the other hand, a ROESY spectrum with no spin diffusion can only compliment an averaged ensemble conformation obtained by molecular dynamics which is generally considered ambiguous.
The breakthrough infections (BTI) during the Delta wave in the general population have been investigated. The BTI reported in the city of Gurugram (Haryana, India) in the month of August, September, and October 2021 were studied. The monthly BTI in August, September, and October 2021 were 26%, 41%, and 76%, which caused an increase in the monthly caseload to 167, 150, and 206 cases, respectively. Mostly, the patients who had comorbidities developed BTI. However, the BTI reported in the Delta wave did not cause a surge in new cases. The surge was noticed only after the emergence of the Omicron variant of the SARS- CoV-2 virus. In Gurugram, 78.3% sero prevalence recorded in September 2021 was due to vaccination and higher infection rate of 59,921 monthly cases reported in April 2021.
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