The Hoveyda–Grubbs (HG) second-generation catalyst (HG-II), a Ru complex with 2-isopropoxybenzylidene ligand, is extensively used for olefin metathesis, the rearrangement of carbon–carbon double bonds. A well-known strategy to control its...
Ligand exchange reactions between a HoveydaGrubbs-type complex and 2-alkoxybenzylidene in a biomolecule assist in the delivery of a ruthenium complex unit to the biomolecule. Complexes having an electron-withdrawing group in their ligands efficiently transfer a ruthenium complex unit onto peptides. This method is also applicable for adenylate kinase, an experimental model protein. The ligand exchange reaction originates from ruthenium-olefin specific interactions and potentially provides a bioorthogonal method for chemical modification of biomacromolecules with transition metal complexes.
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