The aim of the study was the assessment of the concentrations and establishment of mutual relationships between three main protease inhibitors: alpha-1-antitrypsin (AAT), alpha-2-macroglobulin (alpha-2-M) and antithrombin-III (AT-III), and of the total trypsin inhibitory capacity (TIC) in the serum of diabetic and non-diabetic children during adolescence. Forty-nine children (24 girls and 25 boys) with type 1 diabetes mellitus and 24 non-diabetic children (13 girls and 11 boys) were divided according to the Tanner scale into three groups: pre-, peri- and post-pubertal. The concentrations of AAT, alpha-2-M and AT-III were determined by the radial immunodiffusion method on NOR-Partigen plates (Dade-Behring), while TIC was determined by the method using BAPNA as substrate. Means and medians of serum AAT [1.55 g/l, 1.40 (95% confidence interval, 1.42-1.68), respectively] and TIC [10.6 mg trypsin/100 ml, 10.3 (95% CI, 9.5-11.7)] in diabetic children were lower than means and medians of AAT [1.81 g/l, 1.60 (95% CI 1.55-2.07), respectively] and TIC [12.5 mg trypsin/100 ml, 13.2 (95% CI, 10.9-14.1)] in non-diabetic children. A comparison of variables between Tanner groups shows an increasing trend of AAT concentration in diabetic children and a decreasing trend of TIC in non-diabetic subjects. In contrast to pre- and peri-puberty, no correlations were found in the postpubertal period between the studied parameters, either in diabetic or non-diabetic patients. Hyperglycaemia and the duration of diabetes were found to have a significant association with alpha-2-M and AT-III concentrations, but not with AAT serum concentrations. The concentrations and correlations between serum protease inhibitors in diabetic children during adolescence are disrupted compared with non-diabetic children. Taking into account the unfavourable consequences of vascular complications resulting from serum trypsin inhibitor changes and protease- antiprotease imbalance, diabetic children are at greater risk of this occurring during adolescence.
Introduction Obesity is a major health problem in Poland and around the world. Excessive gain in early childhood is an important risk factor for the development of obesity. The aim of the study was to analyze the prevalence of obesity in 2-, 4- and 6-year-old obese children. Material and methods The study group: 656 overweight and obese children aged 5–18 years old. The patients’ height and weight were measured, body mass index (BMI) was calculated. Overweight: BMI between 85 th -97 th percentile and obesity: BMI > 97 th were defined using World Health Organization. BMI < +2 SDS as overweight, BMI ≥ +2 SDS as class I obesity, and BMI ≥ 3 SDS as class II. Measurements from the health books of children aged 2 ( n = 626), 4 ( n = 533) and 6 ( n = 518) years old were analyzed. Results Mean age: 12.25 ±2.90 years, BMI SDS: +2.54 ±0.60. There were 100 overweight (15.2%) and 556 obese (84.8%) children in the group, including 143 patients with class II obesity (21.8%). Children < 10 years old comprised 28%. It was established that 36.6% of the patients were overweight or obese at the age of 2 years old. At the age of 4, the percentage was 73.9%, and at the age of 6, it was as high as 84%. Conclusions 1. The children studied had excess body weight from early childhood. The prevalence of obesity increased with age. 2. Systematic monitoring of developmental parameters in children is essential from an early age.
CD5/ CD20 lymphocyte subsets are a good additional marker of autoimmunological processes in DM.
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