The great potential of lipases is known since 1930 when the work of J. B. S. Haldane was published. After eighty-five years of studies and developments, are lipases still important biocatalysts? For answering this question the present work investigated the technological development of four important industrial sectors where lipases are applied: production of detergent formulations; organic synthesis, focusing on kinetic resolution, production of biodiesel, and production of food and feed products. The analysis was made based on research publications and patent applications, working as scientific and technological indicators, respectively. Their evolution, interaction, the major players of each sector and the main subject matters disclosed in patent documents were discussed. Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment. The results lead to a conclusion that the use of lipases as biocatalysts is still a relevant topic for the industrial sector, but developments are still needed for lipase biocatalysis to reach its full potential, which are expected to be achieved within the third, and present, wave of biocatalysis.

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RESUMOAtualmente estão disponíveis diversas bases de dados online para a busca de documentos de patente. A eleição da base mais apropriada para cada busca vai depender dos objetivos a serem alcançados e precisa levar em consideração as vantagens e desvantagens de cada uma das bases de dados. O presente estudo visa analisar os resultados encontrados nas bases de dados Esp@cenet, PatentScope, USPTO e INPI para a busca baseada em palavras-chave e códigos da Classificação Internacional de Patentes na área de aplicação de lipases para resolução de misturas racêmicas.